{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:05Z","timestamp":1787169665102,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"U.S. Department of Veterans Affairs, Office of Research and Development Clinical Research and Development Program, the Biomedical Laboratory Research Program and NIH","award":["P50AG005136, P50NS062684, K99AG034214\/4R00AG034214"],"award-info":[{"award-number":["P50AG005136, P50NS062684, K99AG034214\/4R00AG034214"]}]},{"name":"University of Washington Alzheimer's Disease Research Center NIH","award":["P50-AB005136"],"award-info":[{"award-number":["P50-AB005136"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Of recent interest is the finding that certain cerebrospinal fluid (CSF) biomarkers traditionally linked to Alzheimer's disease (AD), specifically amyloid beta protein (A\u03b2), are abnormal in PD CSF. The aim of this exploratory investigation was to determine whether genetic variation within the amyloid precursor protein (APP) processing pathway genes correlates with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels in Parkinson's disease (PD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Parkinson's disease (n\u2009=\u200986) and control (n\u2009=\u2009161) DNA were genotyped for 19 regulatory region tagging single\u2010nucleotide polymorphisms (SNPs) within nine genes (\n                      <jats:italic>APP, ADAM10, BACE1, BACE2, PSEN1, PSEN2, PEN2, NCSTN,<\/jats:italic>\n                      and\n                      <jats:italic>APH1B)<\/jats:italic>\n                      involved in the cleavage of APP. The SNP genotypes were tested for their association with CSF biomarkers and PD risk while adjusting for age, sex, and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant correlation with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels in PD was observed for two SNPs, (\n                      <jats:italic>APP<\/jats:italic>\n                      rs466448 and\n                      <jats:italic>APH1B<\/jats:italic>\n                      rs2068143). Conversely, significant correlation with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels in controls was observed for three SNPs (\n                      <jats:italic>APP<\/jats:italic>\n                      rs214484, rs2040273, and\n                      <jats:italic>PSEN1<\/jats:italic>\n                      rs362344).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In addition, results of this exploratory investigation suggest that an\n                      <jats:italic>APP<\/jats:italic>\n                      SNP and an\n                      <jats:italic>APH1B<\/jats:italic>\n                      SNP are marginally associated with PD CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 noncarriers. Further hypotheses generated include that decreased CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels are in part driven by genetic variation in APP processing genes. Additional investigation into the relationship between these findings and clinical characteristics of PD, including cognitive impairment, compared with other neurodegenerative diseases, such as AD, are warranted. \u00a9 2015 International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26172","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T19:29:10Z","timestamp":1427225350000},"page":"936-944","source":"Crossref","is-referenced-by-count":20,"title":["Cerebrospinal fluid A\u03b2\n                    <sub>42<\/sub>\n                    levels and\n                    <i>APP<\/i>\n                    processing pathway genes in Parkinson's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Lynn M.","family":"Bekris","sequence":"first","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation Cleveland Ohio 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Puget Sound Health Care System Seattle Washington USA"},{"name":"Department of Medicine University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Montine","sequence":"additional","affiliation":[{"name":"Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System Seattle Washington USA"},{"name":"Psychiatry and Behavioral Sciences, University of Washington School of Medicine Seattle Washington USA"},{"name":"Department of Neurology University of Washington School of Medicine Seattle Washington USA"},{"name":"Northwest Network Parkinson's Disease Research, Education and Clinical Center (PADRECC), VA Puget Sound Health Care System Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwest Network Mental Illness Research, Education and Clinical Center 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