{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:54:41Z","timestamp":1782910481771,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotropic glutamate receptor 5 antagonist, reduces chorea in Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 32\u2010day randomized, double\u2010blind, parallel\u2010group, proof\u2010of\u2010concept study investigated AFQ056 (25\u2010150 mg [incremental doses], twice\u2010daily) versus placebo in patients with HD. Primary efficacy assessments were the chorea\u2010sum score and orientation index (nondominant hand) from the quantitative motor (Q\u2010Motor) grasping task at day 28. Key secondary efficacy assessments included finger\u2010tapping in the Unified Huntington's Disease Rating Scale\u2013Total Motor Score and Q\u2010Motor measures. Safety and tolerability were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 42 patients were randomized. At day 28, no improvement was observed on the primary efficacy assessments (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.10) with AFQ056 versus placebo. The Q\u2010Motor speeded\u2010tapping interonset interval variability was reduced with AFQ056 versus placebo for the nondominant hand (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The incidence of adverse events was 66.7% with AFQ056 and 57.1% with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AFQ056 did not reduce choreatic movements in HD, but was well tolerated. The clinical relevance of the Q\u2010Motor findings (speeded\u2010tapping) are unknown and may warrant further investigation. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26174","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T02:03:06Z","timestamp":1424138586000},"page":"427-431","source":"Crossref","is-referenced-by-count":77,"title":["A randomized, placebo\u2010controlled trial of AFQ056 for the treatment of chorea in Huntington's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Ralf","family":"Reilmann","sequence":"first","affiliation":[{"name":"George\u2010Huntington\u2010Institute M\u00fcnster Germany"},{"name":"Institute for Clinical Radiology, University of M\u00fcnster M\u00fcnster Germany"},{"name":"Department of Neurodegenerative Diseases and Hertie\u2010Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Rouzade\u2010Dominguez","sequence":"additional","affiliation":[{"name":"Clinical Sciences and Innovation Novartis Pharma AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Saft","sequence":"additional","affiliation":[{"name":"Department of Neurology Huntington Center NRW, Ruhr\u2010University Bochum, St. Josef\u2010Hospital Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd D.","family":"S\u00fcssmuth","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Priller","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rosser","sequence":"additional","affiliation":[{"name":"Cardiff University Schools of Medicine and Biosciences, Neuroscience and Mental Health Research Institute Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Rickards","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry The Barberry Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Sch\u00f6ls","sequence":"additional","affiliation":[{"name":"Clinical Neurogenetics Unit, Center of Neurology and Hertie\u2010Institute for Clinical Brain Research T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Pezous","sequence":"additional","affiliation":[{"name":"IIS Translational Sciences\u2013Early Development Statistical Research, Novartis Pharma AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research, Novartis Pharma AG Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Johns","sequence":"additional","affiliation":[{"name":"Neuroscience Translational Medicine, Novartis Institutes for Biomedical Research Inc. 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