{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:27:35Z","timestamp":1772173655423,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010meta\u2010iodobenzylguanidine (\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010MIBG) myocardial scintigraphy is considered reliable in differentiating idiopathic Parkinson's disease (IPD) from other parkinsonisms, but it is biased by pharmacological treatments. Skin biopsy is not influenced by therapy and has disclosed skin denervation in IPD. Our aims were to compare\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010MIBG scintigraphy and skin biopsy findings in IPD and parkinsonisms to (1) verify whether myocardial and skin denervations are linked; (2) explore the simultaneous extent of the autonomic dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 22 IPD and 11 parkinsonism patients by means of\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010MIBG scintigraphy and skin biopsies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the IPD group, both\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010MIBG scintigraphy and skin biopsy results were abnormal in 91% of patients, showing concordance in 82% of cases. In parkinsonisms, results of both tests were normal in all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      (1) Skin biopsy and\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010MIBG scintigraphy provide comparable results; (2) in IPD, autonomic dysfunctions are often simultaneously widespread at cardiac and skin branches. \u00a9 2015 International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26189","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T03:19:15Z","timestamp":1426562355000},"page":"986-989","source":"Crossref","is-referenced-by-count":27,"title":["Skin biopsy and I\u2010123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: A comparative study"],"prefix":"10.1002","volume":"30","author":[{"given":"Maria Pia","family":"Giannoccaro","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche e NeuroMotorie Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Donadio","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Incensi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e NeuroMotorie Universit\u00e0 di Bologna Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Cason","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Medicina Nucleare, Ospedale Maggiore Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitantonio","family":"Di Stasi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e NeuroMotorie Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesa","family":"Scaglione","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 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