{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:28:47Z","timestamp":1773660527583,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Russian Foundation for Basic Research","award":["13-04-01510 and 14- 04-31665"],"award-info":[{"award-number":["13-04-01510 and 14- 04-31665"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha\u2010synuclein (\u03b1\u2010Syn) species resulting from mutations in the <jats:italic>GBA<\/jats:italic> gene. However, in GD, the relationship between GBA activity and \u03b1\u2010Syn accumulation in biological fluids has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed plasma oligomeric \u03b1\u2010Syn levels, leucocyte GBA activity, and plasma chitotriosidase activity in 21 patients with GD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Negative correlation between plasma oligomeric \u03b1\u2010Syn levels, and leucocyte GBA activity was observed in patients with GD (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.487; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decrease in GBA activity may influence \u03b1\u2010Syn oligomerization, explaining the high risk of PD development in GD patients. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26200","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T03:15:17Z","timestamp":1431400517000},"page":"989-991","source":"Crossref","is-referenced-by-count":27,"title":["Plasma <scp>O<\/scp>ligomeric <scp>A<\/scp>lpha\u2010<scp>S<\/scp>ynuclein <scp>I<\/scp>s <scp>A<\/scp>ssociated <scp>W<\/scp>ith <scp>G<\/scp>lucocerebrosidase <scp>A<\/scp>ctivity in <scp>G<\/scp>aucher <scp>D<\/scp>isease"],"prefix":"10.1002","volume":"30","author":[{"given":"Evgenii","family":"Nuzhnyi","sequence":"first","affiliation":[{"name":"First Pavlov's State Medical University of Saint\u2010Petersburg St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Emelyanov","sequence":"additional","affiliation":[{"name":"First Pavlov's State Medical University of Saint\u2010Petersburg St. Petersburg Russia"},{"name":"Petersburg Nuclear Physics Institute St. Petersburg Russia"},{"name":"St. Petersburg Academic University\u2013Nanothecnology Research and Education Centre RAS St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Boukina","sequence":"additional","affiliation":[{"name":"Medical\u2010genetics Scientific Center Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Usenko","sequence":"additional","affiliation":[{"name":"First Pavlov's State Medical University of Saint\u2010Petersburg St. Petersburg Russia"},{"name":"Petersburg Nuclear Physics Institute St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Yakimovskii","sequence":"additional","affiliation":[{"name":"First Pavlov's State Medical University of Saint\u2010Petersburg St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Medical\u2010genetics Scientific Center Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofya","family":"Pchelina","sequence":"additional","affiliation":[{"name":"First Pavlov's State Medical University of Saint\u2010Petersburg St. Petersburg Russia"},{"name":"Petersburg Nuclear Physics Institute St. Petersburg Russia"},{"name":"St. Petersburg Academic University\u2013Nanothecnology Research and Education Centre RAS St. Petersburg 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