{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:46:17Z","timestamp":1767919577288,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T00:00:00Z","timestamp":1427587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1\u03c1 relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative MR parametric mapping was used to assess differences between 50 preHD subjects and 26 age\u2010 and sex\u2010matched controls. Subjects with preHD were classified into two progression groups based on their CAG\u2010age product (CAP) score; a high and a low\/moderate CAP group. Voxel\u2010wise and region\u2010of\u2010interest analyses were used to assess changes in the quantitative relaxation times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T1\u03c1 showed a significant increase in the relaxation times in the high\u2010CAP group, as compared to controls, largely in the striatum. The T1\u03c1 changes in the preHD subjects showed a significant relationship with CAP score. No significant changes in T2 or T2* relaxation times were found in the striatum. T2* relaxation changes were found in the globus pallidus, but no significant changes with disease progression were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that quantitative T1\u03c1 mapping may provide a useful marker for assessing disease progression in HD. The absence of T2 changes suggests that the T1\u03c1 abnormalities are unlikely owing to altered water content or tissue structure. The established sensitivity of T1\u03c1 to pH and glucose suggests that these factors are altered in HD perhaps owing to abnormal mitochondrial function. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26203","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T08:13:22Z","timestamp":1427616802000},"page":"1107-1114","source":"Crossref","is-referenced-by-count":16,"title":["T1\u03c1 imaging in premanifest Huntington disease reveals changes associated with disease progression"],"prefix":"10.1002","volume":"30","author":[{"given":"Shafik N.","family":"Wassef","sequence":"first","affiliation":[{"name":"Department of Radiology University of Iowa Iowa City Iowa USA"},{"name":"SINAPSE, Iowa Neuroimaging Consortium, Department of Psychiatry University of Iowa Iowa City Iowa 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