{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:02:52Z","timestamp":1789124572454,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The asymptomatic carriers of the Leucine rich repeat kinase 2 (<jats:italic>LRRK2)<\/jats:italic> G2019S mutation represent a population at risk for developing PD. The aim of this study was to assess differences in nonmotor symptoms between nonmanifesting carriers and noncarriers of the G2019S mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred fifty\u2010three subjects participated in this observational cross\u2010sectional multicenter study. Standard questionnaires assessing anxiety, depression, cognition, smell, nonmotor symptoms, and rapid eye movement (REM) sleep behavior were administered. Analyses were adjusted for age, sex, family relations, education, and site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010four carriers were identified. Carriers had higher nonmotor symptoms score on the Nonmotor symptoms (NMS) questionnaire (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). These findings were amplified in carriers older than age 50 y, with higher nonmotor symptoms scores and trait anxiety scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cross\u2010section study, carriers of the G2019S <jats:italic>LRRK2<\/jats:italic> mutation endorsed subtle nonmotor symptoms. Whether these are early features of PD will require a longitudinal study. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26213","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T13:57:36Z","timestamp":1427205456000},"page":"981-986","source":"Crossref","is-referenced-by-count":60,"title":["Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the <i>LRRK2<\/i> gene"],"prefix":"10.1002","volume":"30","author":[{"given":"Anat","family":"Mirelman","sequence":"first","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel\u2010Aviv Medical Center Department of Neurology  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy N.","family":"Alcalay","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons Columbia University New York NY USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Saunders\u2010Pullman","sequence":"additional","affiliation":[{"name":"The Alan and Barbara Mirken Department of Neurology Mount Sinai\u2010Beth Israel Medical Center New York New York USA"},{"name":"Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Yasinovsky","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel\u2010Aviv Medical Center Department of Neurology  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avner","family":"Thaler","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Tel\u2010Aviv Medical Center Department of Neurology  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Neurology  Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Sieratzki Chair in Neurology Tel\u2010Aviv University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the LRRK2 AJ consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2011.240366"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277637.33328.d8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc055509"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000254483.19854.ef"},{"key":"e_1_2_8_6_1","unstructured":"Age Specific Penetrance of the LRRK2 G2019S mutation in the Michael J Fox Ashkenazi Jewish (AJ) LRRK2 Consortium. 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