{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:38:32Z","timestamp":1786995512456,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated tremor in the elderly is commonly diagnosed as essential tremor (ET). The prevalence of tremor increases steeply with increasing age, whereas hereditary tremor is becoming less common. Moreover, late\u2010manifesting tremor seems to be associated with dementia and earlier mortality. We hypothesize that different entities underlie tremor in the elderly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two thousand four hundred forty\u2010eight subjects from the Longitudinal Study of Aging Danish Twins older than 70 y answered screening questions for ET in 2001. Two thousand fifty\u2010six (84%) participants drew Archimedes spirals to measure their tremor severity, and classical aging phenotypes were assessed. A subgroup of 276 individuals fulfilling either screening criteria for ET or being controls were personally assessed. Medications and mortality data are available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The spiral score increased with age. The spiral score correlated with tremor severity. For the whole cohort, mortality was significantly correlated with the spiral score, and higher spiral scores were associated with lower physical and cognitive functioning. Multivariate analysis identified higher spiral scores as an independent risk factor for mortality. In contrast, the ET patients did not show an increased but rather a lower mortality rate although it was not statistically significant. Consistent with a slower than normal aging, they were also physically and cognitively better functioning than controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Because incident tremors beyond 70 y of age show worse aging parameters and mortality than controls and ET, we propose to label it \u2018aging\u2010related tremor\u2019 (ART). This tremor starts later in life and is accompanied by subtle signs of aging both cognitively and physically. More detailed clinical features and pathogenesis warrant further assessment. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26265","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T05:51:48Z","timestamp":1434952308000},"page":"1327-1334","source":"Crossref","is-referenced-by-count":107,"title":["Tremor in the elderly: Essential and aging\u2010related tremor"],"prefix":"10.1002","volume":"30","author":[{"given":"G\u00fcnther","family":"Deuschl","sequence":"first","affiliation":[{"name":"Department of Neurology Universit\u00e4tsklinikum Schleswig\u2010Holstein, Kiel Campus, Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Petersen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, The Danish Twin Registry and the Danish Aging Research Center, University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsklinikum Schleswig\u2010Holstein, Kiel Campus, Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, The Danish Twin Registry and the Danish Aging Research Center, University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Genetics Department of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192393.05850.ec"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.2.113"},{"key":"e_1_2_7_5_1","first-page":"31","volume-title":"Benign essential tremor is not a single entity. In: Yahr MD, ed. Current Concepts of Parkinson Disease and Related Disorders","author":"Marsden CD","year":"1983"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.217"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0347"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23579"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60544-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22755"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b389f1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21553"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101572"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.645"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279339.87987.d7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03374.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt238"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310425.76205.02"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318297ef2b"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000115145.18830.1A"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.805"},{"key":"e_1_2_7_25_1","first-page":"1","article-title":"Essential tremor: a clinical and genetic population study","volume":"36","author":"Larssen T","year":"1960","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/089826439901100103"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825fdeed"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000103236.26934.41"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.10.2.255"},{"issue":"3","key":"e_1_2_7_30_1","first-page":"77","article-title":"Clinical measurement of tremor","volume":"13","author":"Bain PG.","year":"1998","journal-title":"Mov Disord"},{"issue":"2","key":"e_1_2_7_31_1","first-page":"A349","article-title":"of computerized tremor spirography as outcome measure for clinical trials in essential tremor","volume":"74","author":"Haubenberger D","year":"2010","journal-title":"Neurology"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23808"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.8.868"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl190"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70322-7"},{"key":"e_1_2_7_38_1","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.4.659"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.1.61"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.03.009"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099075.19951.8C"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb03129.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22324"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21349"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054771"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195691"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540360079019"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182813242"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02878566"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323389"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24004"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.12.1982"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03122.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216134.88617.de"},{"key":"e_1_2_7_57_1","first-page":"S2","article-title":"Diagnostic criteria for essential tremor and differential diagnosis","volume":"54","author":"Elble RJ.","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_7_58_1","first-page":"1","article-title":"Essential tremor: a clinical and genetic population study","volume":"36","author":"Larsson T","year":"1960","journal-title":"Acta Psychiatr Scand Suppl"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:09:18Z","timestamp":1760969358000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,22]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/mds.26265"],"URL":"https:\/\/doi.org\/10.1002\/mds.26265","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,22]]}}}