{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:04:44Z","timestamp":1790913884849,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIH; R01-NS28127-12 to 16"],"award-info":[{"award-number":["NIH; R01-NS28127-12 to 16"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 NS52318"],"award-info":[{"award-number":["R01 NS52318"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 NS75012"],"award-info":[{"award-number":["R01 NS75012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["NCT00591344"],"award-info":[{"award-number":["NCT00591344"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective, parallel\u2010group, single\u2010center trial. Fifty\u2010one nondemented patients with mild\u2010to\u2010moderate PD were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients in mFC and 20 patients in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) and Stroop (0.3; 0, 0.6; <jats:italic>P<\/jats:italic>\u2009=\u20090.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and Stroop (0.3; 0.1, 0.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), Stroop (0.2; \u22120.1, 0.6; <jats:italic>P<\/jats:italic>\u2009=\u20090.048), and BTA (0.3; 0, 0.8; <jats:italic>P<\/jats:italic>\u2009=\u20090.048). No neurological or cognitive adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides class IV level of evidence that 24 months of PRET or mFC may improve attention and working memory in nondemented patients with mild\u2010to\u2010moderate Parkinson's disease. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26291","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T07:46:43Z","timestamp":1436168803000},"page":"1657-1663","source":"Crossref","is-referenced-by-count":169,"title":["Exercise improves cognition in Parkinson's disease: The PRET\u2010PD randomized, clinical trial"],"prefix":"10.1002","volume":"30","author":[{"given":"Fabian J.","family":"David","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Robichaud","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Leurgans","sequence":"additional","affiliation":[{"name":"Departments of Neurological Sciences and Preventive Medicine Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Kohrt","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine University of Colorado School of Medicine Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Section of Parkinson Disease and Movement Disorders, Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Comella","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Section of Parkinson Disease and Movement Disorders, Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Vaillancourt","sequence":"additional","affiliation":[{"name":"Departments of Applied Physiology and Kinesiology Biomedical Engineering, and Neurology, University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Corcos","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University Chicago Illinois USA"},{"name":"Department of Neurological Sciences Section of Parkinson Disease and Movement Disorders, Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90058-I"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404266776"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23868"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.6.1727"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"e_1_2_7_8_1","first-page":"441","article-title":"Mild cognitive impairment in Parkinson's disease","volume":"102","author":"Goldman JG","year":"2011","journal-title":"Minerva Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.583"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.t01-1-01430"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.03.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000644"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25377"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25380"},{"key":"e_1_2_7_15_1","volume-title":"Parkinson Disease: Fitness Counts","author":"Cianci H.","year":"2006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314539732"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_18_1","unstructured":"Canadian Society for Exercise Physiology. 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