{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:29:32Z","timestamp":1789972172470,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously defined a parkinsonism\u2010related metabolic brain network in rhesus macaques using a high\u2010resolution research positron emission tomography camera. This brief article reports a descriptive pilot study to assess the reproducibility of network activity and regional glucose metabolism in independent parkinsonian macaques using a clinical positron emission tomography\/CT camera.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>[<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose PET scans were acquired longitudinally over 3 months in three drug\u2010na\u00efve parkinsonian and three healthy control cynomolgus macaques. Group difference and test\u2013retest stability in network activity and regional glucose metabolism were evaluated graphically, using all brain images from these macaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing the parkinsonian macaques with the controls, network activity was elevated and remained stable over 3 months. Normalized glucose metabolism increased in putamen\/globus pallidus and sensorimotor regions but decreased in posterior parietal cortices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parkinsonism\u2010related network activity can be reliably quantified in different macaques with a clinical positron emission tomography\/CT scanner and is reproducible over a period typically employed in preclinical intervention studies. This measure can be a useful biomarker of disease process or drug effects in primate models of Parkinson's disease. \u00a92015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26302","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T04:44:15Z","timestamp":1442810655000},"page":"1283-1288","source":"Crossref","is-referenced-by-count":18,"title":["Reproducibility of a Parkinsonism\u2010related metabolic brain network in non\u2010human primates: A descriptive pilot study with FDG PET"],"prefix":"10.1002","volume":"30","author":[{"given":"Yilong","family":"Ma","sequence":"first","affiliation":[{"name":"Center for Neurosciences the Feinstein Institute fo Medical Research  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom H.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute, Toronto Western Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Neurosciences the Feinstein Institute fo Medical Research  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Zuo","sequence":"additional","affiliation":[{"name":"PET Center of Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Koprich","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute, Toronto Western Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Fox","sequence":"additional","affiliation":[{"name":"Movement Disorder Clinic, Toronto Western Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[{"name":"PET Center of Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[{"name":"Center for Neurosciences the Feinstein Institute fo Medical Research  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Brotchie","sequence":"additional","affiliation":[{"name":"Toronto Western Research Institute, Toronto Western Hospital University Health Network  Toronto Ontario 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