{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:13:02Z","timestamp":1779117182201,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hungarian Brain Research Program","award":["KTIA_NAP_13-1-2013-0001"],"award-info":[{"award-number":["KTIA_NAP_13-1-2013-0001"]}]},{"name":"Hungarian National Development Agency","award":["SROP-4.2.2.A-11\/1\/KONV-2012-0017"],"award-info":[{"award-number":["SROP-4.2.2.A-11\/1\/KONV-2012-0017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathophysiology of cervical dystonia is poorly understood. Increased brain iron deposition has been described in different movement disorders. Our aim was to investigate brain iron content in patients with cervical dystonia, using R2* relaxation rate, a validated MRI marker of brain iron level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve female patients with primary focal cervical dystonia (mean age: 45.4\u2009\u00b1\u20098.0 years) and 12 age\u2010matched healthy female subjects (mean age: 45.0\u2009\u00b1\u20098.0 years) underwent 3T MRI to obtain regional R2* relaxation rates of the thalamus, caudate nucleus, putamen, and globus pallidus (GP). Regions of interest were delineated automatically on T1\u2010weighted MRIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>R2* values in the putamen were positively correlated with age. Patients with cervical dystonia showed elevated R2* values in the GP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This pilot study provides the first quantitative support for increased brain iron deposition in cervical dystonia. Further studies are needed to explore the implications of this finding.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26306","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T09:29:04Z","timestamp":1438248544000},"page":"1422-1426","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative assessment of brain iron by <scp>R<\/scp>2* relaxometry in patients with cervical dystonia"],"prefix":"10.1002","volume":"30","author":[{"given":"Zsuzsanna","family":"Aschermann","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pecs Pecs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"Perlaki","sequence":"additional","affiliation":[{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group Pecs Hungary"},{"name":"Pecs Diagnostic Center Pecs 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