{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:11:04Z","timestamp":1782789064098,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to test whether disturbed EEG resting\u2010state functional connectivity and network organization are a potential neurophysiological substrate of cognitive impairment in dementia with Lewy bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EEG recordings were obtained in dementia with Lewy bodies patients, Alzheimer's disease patients and controls, matched for age and sex (N\u2009=\u200966 for each group; 14 [21%] female; mean age: 70 years). We analyzed functional connectivity of band\u2010filtered EEG time series using the phase lag index. Functional brain network topology was analyzed with the minimum spanning tree. Mini\u2013Mental State Examination, Trail Making Test A, and Visual Association Test were used as cognitive measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dementia with Lewy bodies patients showed lower connectivity strength in the alpha frequency band, compared to both controls and Alzheimer's disease patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Functional network topology in dementia with Lewy bodies patients was less efficient and contained less hubs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Network characteristics in Alzheimer's disease patients were in between (but did not differ from) those of the other two groups. In dementia with Lewy bodies patients, lower alpha band phase lag index correlated with Visual Association Test scores and Trail Making Test scores (\u03c1\u2009=\u20090.33 and \u03c1\u2009=\u20090.31, respectively), whereas leaf fraction (a measure of \u2018network efficiency\u2019) correlated with Visual Association Test scores (\u03c1\u2009=\u20090.29) and Mini\u2013Mental State Examination scores (\u03c1\u2009=\u20090.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Functional networks of dementia with Lewy bodies patients are characterized by decreased connectivity strength and a loss of network efficiency and hubs. Severity of these disturbances is related to cognitive impairment, suggesting that network disturbances mediate between neuropathology and the clinical syndrome in dementia with Lewy bodies. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26309","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T02:22:06Z","timestamp":1437013326000},"page":"1785-1793","source":"Crossref","is-referenced-by-count":66,"title":["Loss of <scp>EEG<\/scp><scp>N<\/scp>etwork <scp>E<\/scp>fficiency <scp>I<\/scp>s <scp>R<\/scp>elated to <scp>C<\/scp>ognitive <scp>I<\/scp>mpairment in <scp>D<\/scp>ementia <scp>W<\/scp>ith <scp>L<\/scp>ewy <scp>B<\/scp>odies"],"prefix":"10.1002","volume":"30","author":[{"given":"Edwin","family":"van Dellen","sequence":"first","affiliation":[{"name":"Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Clinical Neurophysiology and MEG Center Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Intensive Care Medicine Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"de Waal","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Epidemiology and Biostatistics VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afina W.","family":"Lemstra","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen J.C.","family":"Slooter","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke L.","family":"Smits","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth C.W.","family":"van 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