{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:27:09Z","timestamp":1790422029306,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Portuguese National Funding Agency for Science, Research and Technology","award":["(FCT; PEst-OE\/SAU\/UI0215\/2011)"],"award-info":[{"award-number":["(FCT; PEst-OE\/SAU\/UI0215\/2011)"]}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"crossref","award":["633003"],"award-info":[{"award-number":["633003"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alpha\u2010synuclein (\u03b1\u2010Syn) is particularly abundant in the vermiform appendix, which makes this structure an anatomical candidate for the initiation of Parkinson's disease (PD) pathology. We hypothesized that history of appendectomy might affect PD clinical onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 295 PD patients enrolled in a comprehensive observational study were asked about past history of appendectomy. Cox's regression, with a time\u2010dependent covariate, explored the effects of appendectomy on age at PD onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients (11.5%) had appendectomy before PD onset. There was no significant effect of appendectomy on age at PD onset for the entire cohort (<jats:italic>P<\/jats:italic>\u2009=\u20090.153). However, among patients with late onset (\u226555 years), we found evidence that those with past appendectomy had more years of life without PD symptoms than patients without appendectomy (<jats:italic>P<\/jats:italic>\u2009=\u20090.040). No association was found for the young\u2010onset group (<jats:italic>P<\/jats:italic>\u2009=\u20090.663).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An apparent relationship was observed between appendectomy and PD onset in the late PD cohort. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26311","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T09:28:51Z","timestamp":1438248531000},"page":"1404-1407","source":"Crossref","is-referenced-by-count":59,"title":["Appendectomy may delay <scp>P<\/scp>arkinson's disease Onset"],"prefix":"10.1002","volume":"30","author":[{"given":"Alexandre","family":"Mendes","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Neurologia Centro Hospitalar do Porto Porto Portugal"},{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biomedica, Instituto Ci\u00eancias Biomedicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Centro Hospitalar do Porto Porto Portugal"},{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biomedica, Instituto Ci\u00eancias Biomedicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Vila\u2010Ch\u00e3","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Centro Hospitalar do Porto Porto Portugal"},{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biomedica, Instituto Ci\u00eancias Biomedicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Moreira","sequence":"additional","affiliation":[{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biomedica, Instituto Ci\u00eancias Biomedicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biomedica, Instituto Ci\u00eancias Biomedicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Dam\u00e1sio","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Centro Hospitalar do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Teixeira\u2010Pinto","sequence":"additional","affiliation":[{"name":"CINTESIS Faculdade de Medicina da Universidade do Porto Porto Portugal"},{"name":"Screening and Test Evaluation Program Sydney School of Public Health, University of Sydney Sydney 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