{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:34Z","timestamp":1761007534946,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential long\u2010term consequences of treatments delaying manifestations of neurodegenerative diseases have not been explored. Using Huntington disease (HD) data and Markov chain Monte Carlo methods, we simulated the effects of therapies with equivalent effects on time to onset of HD and survival with HD. Our results suggest substantial potential trade\u2010offs in effects of these therapies; significant delays in time to onset of HD were accompanied by significant prolongations of survival after onset of HD. Under a variety of assumptions, treatments delaying onset of HD result in some patients likely to have a greater increase in survival with manifest HD compared to delays in time to onset of HD. Our results suggest that future work in HD should be sensitive to the potential existence of such trade\u2010offs and that understanding the preferences of HD patients and the broader HD community will be increasingly important. Future research, trial design, and treatment strategies in HD and other mid\u2010life\u2010onset neurodegenerative disorders should consider the possibility of trade\u2010offs in long\u2010term consequences of disease\u2010modifying treatments. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26318","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:08:25Z","timestamp":1436890105000},"page":"1319-1323","source":"Crossref","is-referenced-by-count":5,"title":["Potential trade\u2010offs in treatment of premanifest Huntington's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Roger L.","family":"Albin","sequence":"first","affiliation":[{"name":"Neurology Service &amp; GRECC, VAAAHS Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan Ann Arbor Michigan USA"},{"name":"Michigan Morris K. Udall Center for Parkinson's Disease Ann Arbor Michigan USA"},{"name":"Michigan Alzheimer's Disease Center Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Burke","sequence":"additional","affiliation":[{"name":"Neurology Service &amp; GRECC, VAAAHS Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1136\/jnnp.66.1.52"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/S0092-8674(00)80623-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1016\/j.neuron.2012.05.009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1038\/mt.2011.219"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1056\/NEJMp1109283"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1001\/archneur.63.6.883"},{"volume-title":"Proceedings of the 3rd International Workshop on Distributed Statistical Computing (DSC 2003)","year":"2003","author":"Plummer M","key":"e_1_2_7_9_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1002\/sim.4512"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1002\/mds.21988"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:09:16Z","timestamp":1760969356000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/mds.26318"],"URL":"https:\/\/doi.org\/10.1002\/mds.26318","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}