{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:56:37Z","timestamp":1785758197901,"version":"3.56.0"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universidad Nacional Autonoma de Mexico","award":["(PAPIIT IN221413)"],"award-info":[{"award-number":["(PAPIIT IN221413)"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnologia","doi-asserted-by":"crossref","award":["(220871)"],"award-info":[{"award-number":["(220871)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions in the frontal lobe. However, the impact of the neurodegeneration on the functional integration of the remaining tissue is unknown. To analyze the clinical impact of these functional changes, we correlated the abnormal functional connectivity found in SCA2 patients with their scores in clinical scales. To obtain the functional connectivity changes, we followed two approaches. In one we used areas with significant cerebellar gray matter atrophy as anchor seeds, and in the other we performed a whole\u2010brain data\u2010driven analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen genetically confirmed SCA2 patients and aged\u2010matched healthy controls participated in the study. Voxel\u2010based morphometry and resting\u2010state functional magnetic resonance imaging (fMRI) were done to analyze structural and functional brain changes. Independent component analysis and dual regression were used for intrinsic network comparison. Significant functional connectivity differences were correlated with the behavioral scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seed\u2010based analysis found reduced functional connectivity within the cerebellum and between the cerebellum and frontal\/parietal cortices. Cerebellar functional connectivity increases were found with parietal, frontal, and temporal areas. Intrinsic network analysis found a functional decrease in the cerebellar network, and increase in the default\u2010mode and fronto\u2010parietal networks. Further analysis showed significant correlations between clinical scores and the abnormal functional connectivity strength.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show significant correlations between functional connectivity changes in key areas affected in SCA2 and these patients' motor and neuropsychological impairments, adding an important insight to our understanding of the pathophysiology of SCA2. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26320","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T04:03:12Z","timestamp":1439006592000},"page":"1391-1399","source":"Crossref","is-referenced-by-count":37,"title":["Functional connectivity changes related to cognitive and motor performance in spinocerebellar ataxia type 2"],"prefix":"10.1002","volume":"30","author":[{"given":"Carlos R.","family":"Hernandez\u2010Castillo","sequence":"first","affiliation":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda\u2014C\u00e1tedras\u2014Instituto de Neuroetologia, Universidad Veracruzana  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Galvez","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Neuroetolog\u00eda Universidad Veracruzana  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto E.","family":"Mercadillo","sequence":"additional","affiliation":[{"name":"C\u00e1tedras CONACYT, \u00c1rea de Neurociencias, Depto. de Biolog\u00eda de la Reproducci\u00f3n Universidad Aut\u00f3noma Metropolitana\u2014Unidad Iztapalapa  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuropsicolog\u00eda, Departamento de Fisiolog\u00eda, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Yescas","sequence":"additional","affiliation":[{"name":"Departamento de Neurogen\u00e9tica y Biolog\u00eda Molecular Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda. Manuel Velasco Suarez  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Martinez","sequence":"additional","affiliation":[{"name":"Departamento de Neurogen\u00e9tica y Biolog\u00eda Molecular Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda. Manuel Velasco Suarez  M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Departamento de Neurogen\u00e9tica y Biolog\u00eda Molecular Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda. 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