{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:39:09Z","timestamp":1787960349213,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the underlying mechanisms of clinical symptoms in dementia with Lewy bodies. The aim of this study was to explore the association between loss of striatal dopamine transporter binding and symptoms in dementia with Lewy bodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five patients with dementia with Lewy bodies underwent single\u2010photon emission computerized tomography brain imaging with N\u2010\u03c9\u2010fluoropropyl\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)nortropane ([\n                      <jats:sup>123<\/jats:sup>\n                      I]FP\u2010CIT). Associations between striatal binding ratios and motor (UPDRS), psychiatric (Neuropsychiatric Inventory; [NPI]), and cognitive (Mini\u2013Mental State Examination [MMSE] and neuropsychological tests) symptoms were assessed by linear regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The explorative analysis showed that the motor UPDRS was negatively associated with putamen dopamine transporter binding, whereas no association with striatal dopamine transporter binding was found for total NPI, hallucinations, apathy, depression, anxiety, and MMSE scores. However, in post\u2010hoc analysis, executive impairment was positively associated with dopamine transporter loss after adjustment of age and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dopamine deficiency in patients with dementia with Lewy bodies was associated with severity of motor symptoms, but did not correlate significantly with ratings of neurobehavioral disturbances or overall cognition. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26327","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T07:39:00Z","timestamp":1437723540000},"page":"118-125","source":"Crossref","is-referenced-by-count":34,"title":["Loss of\n                    <scp>D<\/scp>\n                    opamine\n                    <scp>T<\/scp>\n                    ransporter\n                    <scp>B<\/scp>\n                    inding and\n                    <scp>C<\/scp>\n                    linical\n                    <scp>S<\/scp>\n                    ymptoms in\n                    <scp>D<\/scp>\n                    ementia\n                    <scp>W<\/scp>\n                    ith\n                    <scp>L<\/scp>\n                    ewy\n                    <scp>B<\/scp>\n                    odies"],"prefix":"10.1002","volume":"31","author":[{"given":"Fran\u00e7oise J.","family":"Siepel","sequence":"first","affiliation":[{"name":"Center for Age\u2010Related Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Dalen","sequence":"additional","affiliation":[{"name":"Department of Research Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Gr\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Radiology Haukeland University Hospital Bergen Norway"},{"name":"Department of Physics and Technology University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolbj\u00f8rn S.","family":"Br\u00f8nnick","sequence":"additional","affiliation":[{"name":"TIPS\u2010Regional Center for Clinical Research in Psychosis Stavanger University Hospital Stavanger Norway"},{"name":"Faculty of Social Sciences University of Stavanger Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirza C.","family":"Buter","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Center for Age\u2010Related Medicine Stavanger University Hospital Stavanger Norway"},{"name":"Department of Neurobiology Care Sciences and Society (NVS) Center for Alzheimer Research Division of Neurogeriatrics Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10030724"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.10.946"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10576"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1664-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.4.470"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22702"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"AarslandD RongveA NoreSP et al.Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria.Dement Geriatr Cogn Disord2008;26:445\u2013452.","DOI":"10.1159\/000165917"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000295111"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102013\u2010002642"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1212-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1267-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2276-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000279"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03878.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050025"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046813"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1867-y"},{"key":"e_1_2_8_23_1","first-page":"227","article-title":"Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease","volume":"46","author":"Weintraub D","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22158"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0483-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70138-2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.08.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.114025"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000123248.39847.1D"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70057-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.6.919"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1449"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.059998"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-79"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.058"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000007"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326146.60732.d6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.127878"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22488"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf033"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-9158-1-10"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200512000-00014"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","unstructured":"SiennickiJ BienkiewiczM P\u0142achcinska A.Optimal methodology of SPECT\u2215CT acquisition and processing technique for 123I\u2212DaTSCAN neuroimaging [abstract].AIP Conf Proc2010;1204:217\u2013218.","DOI":"10.1063\/1.3295652"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.061952"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050044"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1922-9"},{"key":"e_1_2_8_48_1","first-page":"359","article-title":"Quantification of striatal dopamine transporters with 123I\u2010FP\u2010CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double\u2010blind, placebo\u2010controlled, crossover study in healthy control subjects","volume":"48","author":"Booij J","year":"2007","journal-title":"J Nucl Med"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0621-0"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws211"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.110122"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:35:59Z","timestamp":1760970959000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/mds.26327"],"URL":"https:\/\/doi.org\/10.1002\/mds.26327","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}