{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:41:53Z","timestamp":1777290113185,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dopa\u2010responsive dystonia is clinically dominated by a combination of dystonia and parkinsonism, both known to be associated with abnormal activity in premotor\u2010motor circuits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To probe premotor\u2010motor excitability, we used a transcranial magnetic stimulation dual pulse conditioning paradigm in 15 genetically confirmed dopa\u2010responsive dystonia patients and 20 controls under different medication states. We also determined silent periods, short\u2010latency afferent inhibition, interhemispheric inhibition, and short\u2010interval intracortical inhibition and facilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In contrast to healthy controls, no motor cortex inhibition was seen after premotor conditioning regardless of the dopaminergic state in patients. The duration of the ipsilateral silent period was increased in the OFF state, and short\u2010latency afferent inhibition was reduced in the ON compared with the OFF state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Premotor\u2010motor circuits appear hyporesponsive in dopa\u2010responsive dystonia. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26365","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T10:26:14Z","timestamp":1438338374000},"page":"1705-1709","source":"Crossref","is-referenced-by-count":15,"title":["Premotor\u2013motor excitability is altered in dopa\u2010responsive dystonia"],"prefix":"10.1002","volume":"30","author":[{"given":"Anne","family":"Weissbach","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics University of Luebeck  Germany"},{"name":"Department of Neurology University of Luebeck  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