{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:06:33Z","timestamp":1789661193493,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For essential tremor, the distribution of age of onset is bimodally distributed, with peaks in adolescence and another in late adulthood. The latter is here referred to as aging\u2010related tremor, and it is considered to be associated with earlier aging and increased mortality. We hypothesize that different tremor networks detected by multichannel electroencephalography (EEG) underlie these two tremor groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated 20 patients with essential tremor separated into two groups and 10 age\u2010 and sex\u2010matched aging\u2010related tremor patients using pooled coherence spectra of the maximally coherent EEG electrodes during a holding task, a pinch grip task, and whilst performing slow hand movements. Functional and effective connectivity at the coupling frequency was estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The maximal coherence was significantly higher in early\u2010onset essential tremor compared with aging\u2010related tremor during the three tasks. Compared with the patients with aging\u2010related tremor, 2 Hz to 40 Hz power, spectral peak frequency, and relative signal\u2010to\u2010noise ratio were not different, but the electromyographic amplitude was significantly greater in essential tremor. The source analysis revealed the well\u2010known cortico\u2010brainstem\u2010cerebello\u2010thalamo\u2010cortical network for classical essential tremor, but patients with aging\u2010related tremor showed a cortico\u2010thalamic network only. The connections between the sources for both tremors were bidirectional. Only the cerebellum and the brainstem showed unidirectional connections in essential tremor and the thalamus in aging\u2010related tremor patients. A second essential tremor group with similar electromyographic amplitudes confirmed the differences between both tremor types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show that the oscillating cerebral networks underlying classical essential tremor and aging\u2010related tremor differ, suggesting a pathophysiological difference. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26410","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T02:48:58Z","timestamp":1441680538000},"page":"1673-1680","source":"Crossref","is-referenced-by-count":47,"title":["Essential and aging\u2010related tremor: Differences of central control"],"prefix":"10.1002","volume":"30","author":[{"given":"Muthuraman","family":"Muthuraman","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rauf","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidist Gebremariam","family":"Mideksa","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"von Helmolt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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