{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:44:39Z","timestamp":1790790279118,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine\u2010rich repeat kinase 2 mutations is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with leucine\u2010rich repeat kinase 2\u2010associated PD, four healthy leucine\u2010rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video\u2010polysomnography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine\u2010rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine\u2010rich repeat kinase 2\u2013associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The sleep phenotype in leucine\u2010rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26412","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T09:40:43Z","timestamp":1444902043000},"page":"1839-1843","source":"Crossref","is-referenced-by-count":28,"title":["Sleep aspects on video\u2010polysomnography in LRRK2 mutation carriers"],"prefix":"10.1002","volume":"30","author":[{"given":"Mickael","family":"Ehrminger","sequence":"first","affiliation":[{"name":"Ecole Normale 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