{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:57:12Z","timestamp":1787500632248,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01 NS073947"],"award-info":[{"award-number":["R01 NS073947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01-NS076843"],"award-info":[{"award-number":["R01-NS076843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01-HL117078"],"award-info":[{"award-number":["R01-HL117078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01-NS088538"],"award-info":[{"award-number":["R01-NS088538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Howard Hughes Medical Institute Summer Research Fellowship through Boston University Department of Neuroscience","award":["5510106"],"award-info":[{"award-number":["5510106"]}]},{"name":"Auspex Pharmaceuticals"},{"name":"Jerry McDonald HD Research Fund, US National Institutes of Health","award":["GN>R01-NS073947"],"award-info":[{"award-number":["GN>R01-NS073947"]}]},{"name":"National Science Foundation","award":["PHY-1444389"],"award-info":[{"award-number":["PHY-1444389"]}]},{"name":"EArly-concept Grants for Exploratory Research (EAGER)","award":["R03 NS082601-01"],"award-info":[{"award-number":["R03 NS082601-01"]}]},{"name":"EArly-concept Grants for Exploratory Research (EAGER)","award":["R01 NS088538-01"],"award-info":[{"award-number":["R01 NS088538-01"]}]},{"name":"EArly-concept Grants for Exploratory Research (EAGER)","award":["R01 HL117078-01"],"award-info":[{"award-number":["R01 HL117078-01"]}]},{"name":"EArly-concept Grants for Exploratory Research (EAGER)","award":["R01 NS073947-01"],"award-info":[{"award-number":["R01 NS073947-01"]}]},{"name":"EArly-concept Grants for Exploratory Research (EAGER)","award":["R01 NS076843-01"],"award-info":[{"award-number":["R01 NS076843-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker in blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to examine candidate microRNAs in plasma to determine whether changes observed in HD brains are detectable in peripheral samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four microRNAs from 26 manifest Huntington's disease, four asymptomatic Huntington's disease gene carriers, and eight controls were quantified in plasma using reverse transcription quantitative polymerase chain reaction. Linear regression was used to assess microRNA levels across control, asymptomatic gene carriers, and manifest patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      miR\u201010b\u20105p (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0068) and miR\u2010486\u20105p (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044) were elevated in Huntington's disease plasma. miR\u201010b\u20105p was decreased in asymptomatic gene carriers as compared with patients with Huntington's disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.049), but no difference between asymptomatic gene carriers and healthy controls was observed (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility. \u00a9 2015 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26457","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T07:04:27Z","timestamp":1447743867000},"page":"1961-1964","source":"Crossref","is-referenced-by-count":45,"title":["Study of plasma\u2010derived miRNAs mimic differences in Huntington's disease brain"],"prefix":"10.1002","volume":"30","author":[{"given":"Andrew G.","family":"Hoss","sequence":"first","affiliation":[{"name":"Department of Neurology Boston University School of Medicine Boston Massachusetts 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