{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:02:04Z","timestamp":1791309724265,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is an apparent contradiction between experimental data showing that the basal ganglia are involved in goal\u2010oriented and routine behaviors and clinical observations. Lesion or disruption by deep brain stimulation of the globus pallidus interna has been used for various therapeutic purposes ranging from the improvement of dystonia to the treatment of Tourette's syndrome. None of these approaches has reported any severe impairment in goal\u2010oriented or automatic movement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>To solve this conundrum, we trained 2 monkeys to perform a variant of a 2\u2010armed bandit\u2010task (with different reward contingencies). In the latter we alternated blocks of trials with choices between familiar rewarded targets that elicit routine behavior and blocks with novel pairs of targets that require an intentional learning process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bilateral inactivation of the globus pallidus interna, by injection of muscimol, prevents animals from learning new contingencies while performance remains intact, although slower for the familiar stimuli. We replicate in silico these data by adding lateral competition and Hebbian learning in the cortical layer of the theoretical model of the cortex\u2013basal ganglia loop that provided the framework of our experimental approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The basal ganglia play a critical role in the deliberative process that underlies learning but are not necessary for the expression of routine movements. Our approach predicts that after pallidotomy or during stimulation, patients should have difficulty with complex decision\u2010making processes or learning new goal\u2010oriented behaviors. \u00a9 2016 <jats:italic>Movement<\/jats:italic> Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26542","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T05:54:51Z","timestamp":1456120491000},"page":"1146-1154","source":"Crossref","is-referenced-by-count":43,"title":["The globus pallidus pars interna in goal\u2010oriented and routine behaviors: Resolving a long\u2010standing paradox"],"prefix":"10.1002","volume":"31","author":[{"given":"Camille","family":"Piron","sequence":"first","affiliation":[{"name":"University of Bordeaux, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, French\u2010Israeli Neuroscience Lab Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kase","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, French\u2010Israeli Neuroscience Lab Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meropi","family":"Topalidou","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, UMR 5293, IMN Bordeaux France"},{"name":"INRIA, Bordeaux Sud\u2010Ouest Talence France"},{"name":"University of Bordeaux, UMR 5800, LABRI, IPB Talence France"},{"name":"CNRS, UMR 5800, LABRI, IPB Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Goillandeau","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR 5293, IMN Bordeaux France"},{"name":"CNRS, UMR 5293, IMN Bordeaux 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