{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:30Z","timestamp":1789972110651,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This phase 2 randomized, double\u2010blind, placebo\u2010controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor \u03b17 agonist AQW051 in patients with Parkinson's disease and levodopa\u2010induced dyskinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with idiopathic Parkinson's disease and moderate to severe levodopa\u2010induced dyskinesia were randomized to AQW051 10 mg (n\u00a0=\u00a024), AQW051 50 mg (n\u00a0=\u00a024), or placebo (n\u00a0=\u00a023) once daily for 28 days. Coprimary end points were change in Modified Abnormal Involuntary Movement Scale and Unified Parkinson's Disease Rating Scale part III scores. Secondary outcomes included pharmacokinetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 67 patients completed the study. AQW051\u2010treated patients experienced no significant improvements in Modified Abnormal Involuntary Movement Scale or Unified Parkinson's Disease Rating Scale part III scores by day 28. AQW051 was well tolerated; the most common adverse events were dyskinesia, fatigue, nausea, and falls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AQW051 did not significantly reduce dyskinesia or parkinsonian severity. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26569","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T20:54:10Z","timestamp":1458334450000},"page":"1049-1054","source":"Crossref","is-referenced-by-count":39,"title":["A Placebo\u2010Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa\u2010Induced Dyskinesia"],"prefix":"10.1002","volume":"31","author":[{"given":"Claudia","family":"Trenkwalder","sequence":"first","affiliation":[{"name":"Paracelsus\u2010Elena Hospital Kassel Germany"},{"name":"Department of Neurosurgery University Medical Center Goettingen Germany"},{"name":"German Parkinson Study Group Marburg 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