{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:20:56Z","timestamp":1791580856915,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Two recent randomized, placebo\u2010controlled trials of putative disease\u2010modifying agents (davunetide, tideglusib) in progressive supranuclear palsy (PSP) failed to show efficacy, but generated data relevant for future trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We provide sample size calculations based on data collected in 187 PSP patients assigned to placebo in these trials. A placebo effect was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total PSP\u2010Rating Scale required the least number of patients per group (N\u2009=\u200951) to detect a 50% change in the 1\u2010year progression and 39 when including patients with \u2264 5 years disease duration. The Schwab and England Activities of Daily Living required 70 patients per group and was highly correlated with the PSP\u2010Rating Scale. A placebo effect was not detected in these scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose the 1\u2010year PSP\u2010Rating Scale score change as the single primary readout in clinical neuroprotective or disease\u2010modifying trials. The Schwab and England Activities of Daily Living could be used as a secondary outcome. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26580","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T07:52:21Z","timestamp":1457337141000},"page":"742-747","source":"Crossref","is-referenced-by-count":41,"title":["Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy"],"prefix":"10.1002","volume":"31","author":[{"given":"Maria","family":"Stamelou","sequence":"first","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"},{"name":"Second Department of Neurology, Attikon University Hospital University of Athens Athens Greece"},{"name":"Movement Disorders Department Hygeia Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Sch\u00f6pe","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Campus Homburg Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wagenpfeil","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Campus Homburg Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Del Ser","sequence":"additional","affiliation":[{"name":"Medical Department Noscira SA, Madrid  Spain"},{"name":"Alzheimer Project Research Unit Fundaci\u00f3n CIEN Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee","family":"Bang","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna Y.","family":"Lobach","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phi","family":"Luong","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Respondek","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AdamL.","family":"Boxer","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"},{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AL\u2010108\u2010231 Investigators, Tauros Investigators, and MDS\u2010Endorsed PSP Study 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