{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:48:13Z","timestamp":1772549293400,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Essential tremor is a neurological condition characterized by tremor during voluntary movement. To date, 3 loci linked to familial essential tremor have been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 48 essential tremor patients in 5 large essential tremor pedigrees in our data set for genetic linkage using an Affymetrix Axiom array. Linkage analysis was performed using an affecteds\u2010only dominant model in SIMWALK2. To incorporate all genotype information, GERMLINE was used to identify genome segments shared identical\u2010by\u2010descent in pairs of affecteds. Exome sequencing was performed in pedigrees showing evidence of linkage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For one family, chromosomes 5 and 18 showed genome\u2010wide significant linkage to essential tremor. Shared segment analysis excluded the 18p11 candidate region and reduced the 5q35 region by 1 megabase. Exome sequencing did not identify a potential causative variant in this region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A locus on chromosome 5 is linked to essential tremor. Further research is needed to identify a causative variant. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26582","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T06:19:22Z","timestamp":1456467562000},"page":"1059-1062","source":"Crossref","is-referenced-by-count":18,"title":["Linkage of familial essential tremor to chromosome 5q35"],"prefix":"10.1002","volume":"31","author":[{"given":"James E.","family":"Hicks","sequence":"first","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine University of Miami Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Konidari","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine University of Miami Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton L.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Stajich","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison E.","family":"Ashley\u2010Koch","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine University of Miami Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Scott","sequence":"additional","affiliation":[{"name":"John P. Hussman Institute for Human Genomics, Miller School of Medicine University of Miami Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03251.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062615"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12231"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.04.024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.04.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.03.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.03.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.06.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.06.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01466.x"},{"issue":"6","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ajmg.b.31085","article-title":"LINGO1 is not associated with Parkinson's disease in German patients","volume":"153","author":"Klebe S","year":"2010","journal-title":"Am J Med Genet B"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.27"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-010-0241-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bacfc9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23846"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23240"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829e700c"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000073"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08250"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01516.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.421"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7156307"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.08.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000173033.32535.23"},{"issue":"14","key":"e_1_2_7_30_1","first-page":"1685","article-title":"Premutation alleles associated with Parkinson disease and essential tremor","volume":"292","author":"Deng H","year":"2004","journal-title":"JAMA"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl120"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm018"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26582","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:08:57Z","timestamp":1760951337000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/mds.26582"],"URL":"https:\/\/doi.org\/10.1002\/mds.26582","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}