{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:33:23Z","timestamp":1790800403038,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health & Welfare, Korea","award":["HI09C1444"],"award-info":[{"award-number":["HI09C1444"]}]},{"name":"Ministry of Health & Welfare, Korea","award":["HI14C1072"],"award-info":[{"award-number":["HI14C1072"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science, ICT, and Future Planning, Korea","award":["NRF-2014M3C7A1046042"],"award-info":[{"award-number":["NRF-2014M3C7A1046042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate whether 3 Tesla susceptibility\u2010weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility\u2010weighted imaging and the nigrostriatal dopaminergic degeneration indicated by <jats:sup>123<\/jats:sup>I\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010N\u2010(3\u2010fluoropropyl)\u2010nortropane single photon emission computerized tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow\u2010up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility\u2010weighted imaging. The performance of susceptibility\u2010weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false\u2010negative cases and 11 false\u2010positive cases. The sensitivity and specificity of susceptibility\u2010weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility\u2010weighted imaging and single photon emission computerized tomography was 86.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The loss of nigral hyperintensity on susceptibility\u2010weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by <jats:sup>123<\/jats:sup>I\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010N\u2010(3\u2010fluoropropyl)\u2010nortropane single photon emission computerized tomography. In consideration of false\u2010negative and \u2010positive cases, well\u2010designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26584","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T22:19:38Z","timestamp":1458339578000},"page":"684-692","source":"Crossref","is-referenced-by-count":114,"title":["Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With <sup>123<\/sup>I\u2010FP\u2010CIT SPECT"],"prefix":"10.1002","volume":"31","author":[{"given":"Yun Jung","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Radiology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"},{"name":"Department of Radiology Kyung Hee University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Hallym University Sacred Heart Hospital Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Seok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Chungnam National University Hospital Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology Ewha Womans University Mokdong Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Chungbuk National University Hospital Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute Gachon University of Medicine and Science Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomseok","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Korea"},{"name":"Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology, Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22592"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829e6fd2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131448"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1437"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093814"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000398"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4158"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26171"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4412"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"S2","article-title":"Diagnostic criteria for essential tremor and differential diagnosis","volume":"54","author":"Elble RJ","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10573"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.11.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.086959"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.100784"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6108-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20537"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.231"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200505000-00005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22719"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70047-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000960"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25844"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26431"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:41:20Z","timestamp":1760971280000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1002\/mds.26584"],"URL":"https:\/\/doi.org\/10.1002\/mds.26584","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}