{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:03:41Z","timestamp":1790100221675,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"crossref","award":["5264"],"award-info":[{"award-number":["5264"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BA\/BS-MD Program at the University of Colorado Denver"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fatigue is a common and debilitating nonmotor symptom of PD. Because preliminary evidence suggests that acupuncture improves fatigue in other conditions, we sought to test its efficacy in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010four PD patients with moderate\u2010to\u2010high fatigue were randomized to receive 6 weeks of biweekly real or sham acupuncture. The primary outcome was change on the Modified Fatigue Impact Scale at 6 weeks. Secondary outcomes included sleep, mood, quality of life, and maintenance of benefits at 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed significant improvements in fatigue at 6 and 12 weeks, but with no significant between\u2010group differences. Improvements from baseline in mood, sleep, and quality of life were noted without between\u2010group differences. Overall, 63% of patients reported noticeable improvements in their fatigue. No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acupuncture may improve PD\u2010related fatigue, but real acupuncture offers no greater benefit than sham treatments. PD\u2010related fatigue should be added to the growing list of conditions that acupuncture helps primarily through nonspecific or placebo effects. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26597","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T09:52:45Z","timestamp":1459417965000},"page":"1027-1032","source":"Crossref","is-referenced-by-count":74,"title":["Randomized, Controlled Trial of Acupuncture for Fatigue in Parkinson's Disease"],"prefix":"10.1002","volume":"31","author":[{"given":"Benzi M.","family":"Kluger","sequence":"first","affiliation":[{"name":"Departments of Neurology and Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Rakowski","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Medicine University of Colorado Anschutz Medical Campus 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