{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:35:22Z","timestamp":1782462922306,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Few neurophysiological studies have investigated cerebellar function in patients with essential tremor, even though the cerebellum may contribute to tremor generation. Here, we studied cerebellar function in patients with essential tremor using 2 physiological methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were 20 patients with essential tremor and 30 age\u2010matched healthy volunteers, and the results were compared across the groups. We studied motor cortical inhibition using cerebellar magnetic stimulation and prism adaptation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both cerebellar inhibition and prism adaptation were affected in patients with essential tremor. The degree of tremor did not correlate with the degree of abnormality in either of the 2 experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The simplest explanation for the present results is that the cerebellum itself, including the Purkinje cells, is involved in essential tremor, which may reflect a primary pathogenic lesion or secondary compensatory physiological phenomenon to an original pathogenic lesion elsewhere. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26629","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T14:14:56Z","timestamp":1460297696000},"page":"1230-1234","source":"Crossref","is-referenced-by-count":41,"title":["Cerebellar dysfunction in essential tremor"],"prefix":"10.1002","volume":"31","author":[{"given":"Ritsuko","family":"Hanajima","sequence":"first","affiliation":[{"name":"Department of Neurology Kitasato University School of Medicine Sagamihara Kanagawa Japan"},{"name":"Department of Neurology University of Tokyo Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Tokyo Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Shirota","sequence":"additional","affiliation":[{"name":"Department of Neurology Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kitasato University School of Medicine Sagamihara Kanagawa Japan"},{"name":"Department of Neurology University of Tokyo Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ugawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr164"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.003"},{"key":"e_1_2_6_5_1","article-title":"Linking essential tremor to the cerebellum: neuropathological evidence","author":"Louis ED","year":"2015","journal-title":"Cerebellum"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.08.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv225"},{"key":"e_1_2_6_9_1","article-title":"Atrophy of the cerebellar vermis in essential tremor: segmental volumetric MRI analysis","author":"Shin H","year":"2015","journal-title":"Cerebellum"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg132"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22479"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370603"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-5597(97)00051-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.4.1183"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.4.1960"},{"issue":"3","key":"e_1_2_6_16_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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