{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:40:02Z","timestamp":1768884002733,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The centrum medianum\u2010 parafascicular complex of the human thalamus has a critical influence on cortical activity and significantly influences somatosensory function, arousal, and attention. In addition to its cortical connections, this region of the intralaminar thalamic nuclei is also connected to motor areas of the basal ganglia and the brain stem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to identify movement\u2010related neurons in the centrum medianum\u2010parafascicular complex and analyze the changes in their activity during voluntary movements in patients with cervical dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010unit activity was recorded during the micro\u2010electrode\u2010guided surgical ablation procedures in patients with cervical dystonia. The neural responses and synchronous electromyographic signals of the neck and finger flexor muscles were simultaneously recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found the following 3 types of movement\u2010sensitive neurons in the centrum medianum\u2010parafascicular complex: neurons that responded selectively to voluntary hand movement (hand\u2010only neurons), neurons that selectively responded to neck movements (neck\u2010only neurons), neurons responding to both hand and neck movements (combined neurons). We discovered the following 3 patterns of movement\u2010related changes in neural activity: an increase in the firing rate, a reduction in the bursting activity, and short\u2010term oscillations and synchronization with neighboring neurons. The most pronounced and prolonged responses were observed during movements involving neck muscles as well as during involuntary dystonic movements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The centrum medianum\u2010parafascicular complex of the thalamus is a component of the subcortical network that participates in motor behavior and may be involved in the pathophysiology of cervical dystonia. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26653","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T12:37:23Z","timestamp":1462019843000},"page":"1398-1404","source":"Crossref","is-referenced-by-count":8,"title":["Participation of the thalamic CM\u2010Pf complex in movement performance in patients with dystonia"],"prefix":"10.1002","volume":"31","author":[{"given":"Ulia","family":"Semenova","sequence":"first","affiliation":[{"name":"Semenov Institute of Chemical 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