{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:23:38Z","timestamp":1789917818100,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Physician Services Incorporated"},{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Career Investigator Award from the Heart and Stroke Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pathogenic movement of alpha\u2010synuclein from the gut to the brain in PD has been proposed. The appendix has a relatively high density of alpha\u2010synuclein deposition in neurologically healthy individuals. We investigated the incidence of PD after appendectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using cause\u2010specific hazards regression models, we compared persons over 35 years of age who had undergone appendectomy with two groups of age\u2010 and sex\u2010matched individuals having had: (1) a cholecystectomy and (2) neither procedure. Subsequent diagnoses of PD were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 42,999 individuals undergoing appendectomy, no difference in risk of PD was identified compared to cholecystectomy (hazard ratio\u2009=\u20091.004; 95% confidence interval: 0.740\u20131.364). Compared with no procedure, individuals with appendectomy had a higher incidence of PD within 5 years, but no significant difference in risk thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, appendectomy in mid or late life does not appear to be associated with a reduced risk of PD. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26670","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T03:26:38Z","timestamp":1464665198000},"page":"1243-1247","source":"Crossref","is-referenced-by-count":57,"title":["Appendectomy in mid and later life and risk of Parkinson's disease: A population\u2010based study"],"prefix":"10.1002","volume":"31","author":[{"given":"Connie","family":"Marras","sequence":"first","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada University of Toronto Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Austin","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences and the University of Toronto Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lau","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences and the University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Urbach","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Evaluative Sciences and the University of Toronto Toronto Ontario Canada"},{"name":"Toronto General Research Institute, University Health Network, Department of Surgery Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1:2","article-title":"The prion hypothesis in Parkinson's disease: Braak to the future","author":"Visanji NP","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0956-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25779"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008762"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24448"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26311"},{"key":"e_1_2_8_9_1","unstructured":"JuurlinkD PreyraC CroxfordR et al.Canadian Institute for Health Information Discharge Abstract Database: a validation study. 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