{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:41:37Z","timestamp":1784266897352,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Innsbruck Medical University","award":["IFTZ 2007152"],"award-info":[{"award-number":["IFTZ 2007152"]}]},{"name":"Austrian Society of Neurology"},{"name":"Erwin Schr\u00f6dinger Fellowship in Epidemiology from the Austrian Science Fund","award":["J 3679-B13"],"award-info":[{"award-number":["J 3679-B13"]}]},{"name":"Pustertaler Verein zur Pr\u00e4vention von Herz- und Hirngefaesserkrankungen"},{"name":"Gesundheitsbezirk Bruneck"},{"name":"the mayor of Bruneck"},{"name":"\u201cAssessorat fuer Gesundheit,\u201d Province of Bolzano, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, the International Parkinson and Movement Disorder Society has defined research criteria for prodromal Parkinson's disease (PD), but to date their predictive value has not yet been tested in population\u2010based cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively applied these criteria to the longitudinal Bruneck Study cohort aged 55\u201094 years using recorded data on all included risk and prodromal markers that are quick and easily assessable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After excluding participants with idiopathic PD or secondary parkinsonism, prevalence of probable prodromal PD in the remaining 539 participants was 2.2% (95% confidence interval, 1.2%\u20103.9%). Of 488 participants followed up over 5 years, 11 developed incident PD. Sensitivity of \u201cprobable prodromal PD\u201d status for incident PD was 54.6% (95% confidence interval, 28.0%\u201078.8%), specificity was 99.2% (97.8%\u201099.8%), positive predictive value was 60.0% (31.2%\u201083.3%), and negative predictive value was 99.0% (97.5%\u201099.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the new research criteria for prodromal PD are a promising tool to identify cases of incident PD over 5 years, arguing for their usefulness in defining target populations for disease\u2010prevention trials. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26674","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T09:44:48Z","timestamp":1465206288000},"page":"1405-1408","source":"Crossref","is-referenced-by-count":85,"title":["Prodromal Parkinson's disease as defined per MDS research criteria in the general elderly community"],"prefix":"10.1002","volume":"31","author":[{"given":"Philipp","family":"Mahlknecht","sequence":"first","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"},{"name":"Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Gasperi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital of Bruneck Bruneck Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"},{"name":"King's British Heart Foundation Centre King's College London London United Kingdom"},{"name":"Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiechl","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Stockner","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Rungger","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital of Bruneck Bruneck Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sawires","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nocker","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Rastner","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherina J.","family":"Mair","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hotter","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University Innsbruck 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