{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:02Z","timestamp":1790617202598,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24590691"],"award-info":[{"award-number":["24590691"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Leptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 55 patients and 25 age\u2010matched healthy controls in this study. Associations between head\u2010up tilt test measurements and leptin levels were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systolic blood pressure changes during the head\u2010up tilt tests were strongly correlated with leptin levels at baseline and at a 60\u2010degree head\u2010up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These observations suggest that low leptin levels may be associated with orthostatic hypotension during the head\u2010up tilt test in patients with PD. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26678","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T09:44:48Z","timestamp":1465206288000},"page":"1417-1421","source":"Crossref","is-referenced-by-count":19,"title":["Association of leptin with orthostatic blood pressure changes in Parkinson's disease"],"prefix":"10.1002","volume":"31","author":[{"given":"Tomohiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan"},{"name":"Department of Laboratory 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