{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:32:44Z","timestamp":1787110364608,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KL 1433\/2-1"],"award-info":[{"award-number":["KL 1433\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KU1194\/9-1 KU1194\/8-1"],"award-info":[{"award-number":["KU1194\/9-1 KU1194\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["De 438\/16"],"award-info":[{"award-number":["De 438\/16"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["SFB 855 1261"],"award-info":[{"award-number":["SFB 855 1261"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Essential tremor is a very common disease defined by sparse clinical criteria. It is unlikely that essential tremor is an etiologically homogeneous disease. Stratifying broadly defined diseases using clinical characteristics has often aided the etiopathological understanding. Most studies of essential tremor show 2 distinct age at onset peaks: early and late. This study investigates phenotypical differences between early\u2010 and late\u2010onset essential tremor patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied a sample of 1137 tremor patients. Of these patients, 978 suffered from definite or probable essential tremor. All of the patients underwent the same standardized examination encompassing, among other items, drawing of the Archimedes spiral and assessment of the Fahn\u2010Tolosa\u2010Marin scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two subgroups of early\u2010onset (\u2264 24 years of age, n = 317) and late\u2010onset (\u2265 46 years of age, n = 356) patients were selected based on the visual and mathematical analysis of the age\u2010at\u2010onset distribution. Tremor severity in both groups was comparable. Tremor progression measured as Archimedes spiral score and the Fahn\u2010Tolosa\u2010Marin subscales divided by the disease duration in 10\u2010year bins was significantly faster in late\u2010onset patients when compared with early\u2010onset patients. Early\u2010onset patients more frequently reported a positive family history and alcohol sensitivity of the tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The age\u2010at\u2010onset distribution suggests a distinction between early\u2010 and late\u2010onset tremor. Early\u2010onset and late\u2010onset essential tremor differ in the progression rates and the frequencies of a positive family history and history of a positive effect of alcohol on tremor. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26708","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T01:26:52Z","timestamp":1467854812000},"page":"1560-1566","source":"Crossref","is-referenced-by-count":75,"title":["Early\u2010 and late\u2010onset essential tremor patients represent clinically distinct subgroups"],"prefix":"10.1002","volume":"31","author":[{"given":"Franziska","family":"Hopfner","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjuli","family":"Ahlf","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Klebe","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E.","family":"Zeuner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kuhlenb\u00e4umer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Deuschl","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Schleswig Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23878"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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