{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:27:20Z","timestamp":1769837240159,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>DYT1<\/jats:italic> mutation is characterized by focal to generalized dystonia and incomplete penetrance. To explore the complex perturbations in the different neural networks and the mutual interactions among them, we studied symptomatic and asymptomatic DTY1 mutation carriers by resting\u2010state functional MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 7 symptomatic <jats:italic>DYT1<\/jats:italic>, 10 asymptomatic <jats:italic>DYT1<\/jats:italic>, and 26 healthy controls were considered. Resting\u2010state functional MRI (Oxford Centre for Functional MRI of the Brain) [FMRIB] Software Library) (FSL) MELODIC, dual regression, (as a toolbox of FSL, with Nets is referred to \u201cnetworks\u201d) (FSLNets) (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/fsl.fmrib.ox.ac.uk\/fsl\/fslwiki\/FSLNets\">http:\/\/fsl.fmrib.ox.ac.uk\/fsl\/fslwiki\/FSLNets<\/jats:ext-link>) was performed on 9 resting\u2010state neural networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>DYT1<\/jats:italic> mutation signature (symptomatic <jats:italic>DYT1<\/jats:italic> and asymptomatic <jats:italic>DYT1<\/jats:italic>) was characterized by increased connectivity in the dorsal attention network and in the left fronto\u2010parietal network. Functional correlates of symptomatic <jats:italic>DYT1<\/jats:italic> patients (symptomatic <jats:italic>DYT1<\/jats:italic> vs healthy controls) showed increased connectivity in the sensorimotor network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study argues that <jats:italic>DYT1<\/jats:italic> dystonia is a network disorder, with crucial nodes in sensory\u2010motor integration of posterior parietal structures. A better characterization of cortical networks involved in dystonia is crucial for possible neurophysiological therapeutic interventions. \u00a9 2016 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26725","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T04:53:46Z","timestamp":1469422426000},"page":"1739-1743","source":"Crossref","is-referenced-by-count":12,"title":["Functional Connectivity Networks in Asymptomatic and Symptomatic <i>DYT1<\/i> Carriers"],"prefix":"10.1002","volume":"31","author":[{"given":"Enrico","family":"Premi","sequence":"first","affiliation":[{"name":"Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Diano","sequence":"additional","affiliation":[{"name":"GCS fMRI Koelliker Hospital Turin 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