{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:44:13Z","timestamp":1790631853933,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The study of functional connectivity by means of magnetic resonance imaging (MRI) in asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers could contribute to the characterization of the prediagnostic phase of\n                      <jats:italic>LRRK2<\/jats:italic>\n                      \u2010associated Parkinson's disease (PD). The objective of this study was to characterize MRI functional patterns during the resting state in asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We acquired structural and functional MRI data of 18 asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers and 18 asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation noncarriers, all first\u2010degree relatives of\n                      <jats:italic>LRRK2<\/jats:italic>\n                      \u2010PD patients. Starting from resting\u2010state data, we analyzed the functional connectivity of the striatocortical and the nigrocortical circuitry. Structural brain data were analyzed by voxel\u2010based morphometry, cortical thickness, and volumetric measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers had functional connectivity reductions between the caudal motor part of the left striatum and the ipsilateral precuneus and superior parietal lobe. Connectivity in these regions correlated with subcortical gray\u2010matter volumes in mutation carriers. Asymptomatic carriers also showed increased connectivity between the right substantia nigra and bilateral occipital cortical regions (occipital pole and cuneus bilaterally and right lateral occipital cortex). No intergroup differences in structural MRI measures were found. In\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers, age and functional connectivity correlated negatively with striatal volumes. Additional analyses including only subjects with the G2019S mutation revealed similar findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Asymptomatic\n                      <jats:italic>LRRK2<\/jats:italic>\n                      mutation carriers showed functional connectivity changes in striatocortical and nigrocortical circuits compared with noncarriers. These findings support the concept that altered brain connectivity precedes the onset of classical motor features in a genetic form of PD. \u00a9 2016 International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26799","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T09:26:41Z","timestamp":1474450001000},"page":"1820-1828","source":"Crossref","is-referenced-by-count":46,"title":["Nigral and striatal connectivity alterations in asymptomatic\n                    <i>LRRK2<\/i>\n                    mutation carriers: A magnetic resonance imaging study"],"prefix":"10.1002","volume":"31","author":[{"given":"Dolores","family":"Vilas","sequence":"first","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e0rbara","family":"Segura","sequence":"additional","affiliation":[{"name":"Psychiatry and Clinical Psychobiology Department Universitat de Barcelona. Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo C.","family":"Baggio","sequence":"additional","affiliation":[{"name":"Psychiatry and Clinical Psychobiology Department Universitat de Barcelona. Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claustre","family":"Pont\u2010Sunyer","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro en Red para la Investigacion de Enfermedades Neurodegenerativas CIBERNED Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Valldeoriola","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro en Red para la Investigacion de Enfermedades Neurodegenerativas CIBERNED Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Jos\u00e9 Mart\u00ed","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro en Red para la Investigacion de Enfermedades Neurodegenerativas CIBERNED Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Quintana","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angels","family":"Bay\u00e9s","sequence":"additional","affiliation":[{"name":"Parkinson's Unit Cl\u00ednica Teknon Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Hern\u00e1ndez\u2010Vara","sequence":"additional","affiliation":[{"name":"Neurology Service Hospital Universitari Vall D'Hebron Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Calopa","sequence":"additional","affiliation":[{"name":"Neurology Service Hospital Universitari de Bellvitge Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Neurology Service Hospital Universitari Mutua de Terrasa Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Junqu\u00e9","sequence":"additional","affiliation":[{"name":"Psychiatry and Clinical Psychobiology Department Universitat de Barcelona. 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