{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:28:12Z","timestamp":1790699292378,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Somatosensory temporal discrimination threshold is often prolonged in patients with dystonia. Previous evidence suggested that this might be caused by impaired somatosensory processing in the time domain. Here, we tested if other markers of reduced inhibition in the somatosensory system might also contribute to abnormal somatosensory temporal discrimination in dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Somatosensory temporal discrimination threshold was measured in 19 patients with isolated cervical dystonia and 19 age\u2010matched healthy controls. We evaluated temporal somatosensory inhibition using paired\u2010pulse somatosensory evoked potentials, spatial somatosensory inhibition by measuring the somatosensory evoked potentials interaction between simultaneous stimulation of the digital nerves in thumb and index finger, and Gamma\u2010aminobutyric acid\u2010ergic (GABAergic) sensory inhibition using the early and late components of high\u2010frequency oscillations in digital nerves somatosensory evoked potentials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When compared with healthy controls, dystonic patients had longer somatosensory temporal discrimination thresholds, reduced suppression of cortical and subcortical paired\u2010pulse somatosensory evoked potentials, less spatial inhibition of simultaneous somatosensory evoked potentials, and a smaller area of the early component of the high\u2010frequency oscillations. A logistic regression analysis found that paired pulse suppression of the N20 component at an interstimulus interval of 5 milliseconds and the late component of the high\u2010frequency oscillations were independently related to somatosensory temporal discrimination thresholds. \u201cDystonia group\u201d was also a predictor of enhanced somatosensory temporal discrimination threshold, indicating a dystonia\u2010specific effect that independently influences this threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased somatosensory temporal discrimination threshold in dystonia is related to reduced activity of inhibitory circuits within the primary somatosensory cortex. \u00a9 2016 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26804","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T03:17:07Z","timestamp":1474946227000},"page":"141-148","source":"Crossref","is-referenced-by-count":73,"title":["Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia"],"prefix":"10.1002","volume":"32","author":[{"given":"Elena","family":"Antelmi","sequence":"first","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London London UK"},{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna Bologna Italy"},{"name":"IRCSS, Istituto di Ricovero e Cura a Carattere Scientifico; Research Hospital, Institute of Neurological Sciences Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Erro","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London London UK"},{"name":"Department of Neuroscience, Biomedicine and Movement Science University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Rocchi","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London London UK"},{"name":"Department of Neurology and Psychiatry \u201cSapienza\u201d University of Rome  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna Bologna Italy"},{"name":"IRCSS, Istituto di Ricovero e Cura a Carattere Scientifico; Research Hospital, Institute of Neurological Sciences Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Science University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Di Stasio","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry \u201cSapienza\u201d University of Rome  Italy"},{"name":"IRCCS Neuromed, Pozzilli (IS)  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Berardelli","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry \u201cSapienza\u201d University of Rome  Italy"},{"name":"IRCCS Neuromed, Pozzilli (IS)  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.12.1077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3758\/APP.71.4.860"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25822"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.04.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4210-03.2004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032979"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg219"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10525"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131524"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21870"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.178236"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199905140-00028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200101)16:1<94::AID-MDS1020>3.0.CO;2-O"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23447"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl283"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.12.1869"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.1.42"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.02.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.05.023"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2008-15.2016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.08.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00144"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.06.023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp156"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.10.016"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_7_28_1","first-page":"3","article-title":"The ten\u2010twenty electrode system of the International Federation. 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