{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:25:34Z","timestamp":1790371534597,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"LabEx DISTALZ"},{"name":"Association PSP France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule\u2010associated protein tau gene correlates with the expression changes in Alzheimer's disease and Parkinson's disease brains. However, few studies examine the sequences beyond the constitutive promoter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Because activating different microtubule\u2010associated protein tau gene control regions via methylation might regulate the differential tau expression constituting the specific signatures of individual tauopathies, we compared methylation of a candidate promoter, intron 0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed DNA methylation in the brains of patients with different tauopathies (35 Alzheimer's disease, 10 corticobasal degeneration, and 18 PSP) and 19 controls by intron 0 pyrosequencing. We also evaluated methylation in an independent cohort of 11 PSP cases and 12 controls. Frontal (affected by tau pathology) and occipital (unaffected) cortices were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the initial samples, one CpG island site in intron 0 (CpG1) showed significant hypomethylation in PSP\u2010affected frontal cortices when compared with controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.022). Such hypomethylation was observed in replicate samples, but not in occipital cortices or other tauopathies. PSP and control samples (combining the initial and replicate samples) remained significantly different after adjustment for potential confounding factors (age, H1\/H1 diplotype;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0005). PSP\u2010affected tissues exhibited microtubule\u2010associated protein tau RNA hyperexpression when compared with controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004), although no correlation with CpG1 methylation was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This exploratory study suggests that regions other than the constitutive promoter may be involved in microtubule\u2010associated protein tau gene regulation in tauopathies and that intron 0 hypomethylation may be a specific epigenetic signature of PSP. These preliminary findings require confirmation. \u00a9 2016 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26820","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T18:01:07Z","timestamp":1476295267000},"page":"1883-1890","source":"Crossref","is-referenced-by-count":35,"title":["<scp>T<\/scp>\n                    he\n                    <scp>\n                      <i>MAPT<\/i>\n                    <\/scp>\n                    gene is differentially methylated in the progressive supranuclear palsy brain"],"prefix":"10.1002","volume":"31","author":[{"given":"Vincent","family":"Huin","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S 1172 \u2010 JPArc \u2010 Centre de Recherche Jean\u2010Pierre AUBERT Neurosciences et Cancer Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8201-5406","authenticated-orcid":false,"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S 1172 \u2010 JPArc \u2010 Centre de Recherche Jean\u2010Pierre AUBERT Neurosciences et Cancer Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Caparros\u2010Lefebvre","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Wattrelos, Service de Neurologie Wattrelos France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude\u2010Alain","family":"Maurage","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S 1172 \u2010 JPArc \u2010 Centre de Recherche Jean\u2010Pierre AUBERT Neurosciences et Cancer Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Duyckaerts","sequence":"additional","affiliation":[{"name":"Laboratoire de Neuropathologie Escourolle, AP\u2010HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eniko","family":"Kovari","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Psychiatry University Hospitals and University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pasquier","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1171 \u2010 CNR\u2010MAJ, DISTALZ Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bu\u00e9e\u2010Scherrer","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, UMR\u2010S 1172 \u2010 JPArc \u2010 Centre de Recherche Jean\u2010Pierre AUBERT Neurosciences et Cancer Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, EA 2694 \u2010 Sant\u00e9 publique : \u00e9pid\u00e9miologie et qualit\u00e9 des soins, D\u00e9partement de Statistiques Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Behal","sequence":"additional","affiliation":[{"name":"Univ. 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