{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:11:18Z","timestamp":1790665878783,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The pathophysiology of pain in Parkinson's disease (PD) is still poorly understood, although it is conceivable that supraspinal mechanisms may be responsible for pain generation and maintenance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined brain functional and anatomical changes associated with persistent pain in 40 PD patients, 20 with persistent pain and 20 without pain. We also examined 15 pain\u2010free healthy participants of similar age, gender, and cognitive state as a control group. We assessed pain by the King's Parkinson's Pain Scale, the Visual Analogue Scale for pain, and the Leeds Assessment for Neuropathic Symptoms and Sign. All patients underwent structural, diffusion tensor imaging, and resting\u2010state functional MRI. We compared clinical characteristics, whole\u2010brain cortical thickness, subcortical volumes, diffusion tensor imaging scalar measures, and functional connectivity by network based statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The group with PD and persistent pain showed significant thinning in the bilateral temporal pole, left\u2010medial orbitofrontal cortex, bilateral superior and left\u2010inferior parietal areas, pars orbicularis, and right superior frontal, posterior cingulated, and precentral cortex. There were no significant subcortical volume and white matter differences between PD subgroups. Functional MRI showed a decrease of brain activity in the left frontal inferior orbital in PD patients with persistent pain, with greater activity bilaterally in the cerebellum and in the right inferior temporal areas. Only PD patients with persistent pain showed an accumbens\u2013hippocampus disconnection without white matter and subcortical alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed that persistent pain in PD is associated with supraspinal structural and functional changes. We also highlighted the contribution of frontal, prefrontal, and insular areas in nociceptive modulation and accumbens\u2013hippocampus disconnection. \u00a9 2016 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.26826","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T13:42:50Z","timestamp":1476279770000},"page":"1854-1864","source":"Crossref","is-referenced-by-count":69,"title":["Anatomical and functional correlates of persistent pain in Parkinson's disease"],"prefix":"10.1002","volume":"31","author":[{"given":"Andrea","family":"Polli","sequence":"first","affiliation":[{"name":"Parkinson Unit, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Rehabilitation Hospital Venice Italy"},{"name":"Laboratory of Robotics and Kinematics, Neurorehabilitation Department, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Hospital Foundation Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Weis","sequence":"additional","affiliation":[{"name":"Parkinson Unit, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Rehabilitation Hospital Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Biundo","sequence":"additional","affiliation":[{"name":"Parkinson Unit, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Rehabilitation Hospital Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thacker","sequence":"additional","affiliation":[{"name":"Centre for Human and Aerospace Physiological Sciences, Pain Section, Neuroimaging, Institute of Psychiatry, Kings College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Turolla","sequence":"additional","affiliation":[{"name":"Laboratory of Robotics and Kinematics, Neurorehabilitation Department, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Hospital Foundation Venice Italy"},{"name":"Department of Neuroscience The University of Sheffield Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostantinos","family":"Koutsikos","sequence":"additional","affiliation":[{"name":"Parkinson Unit, Institute for Research, Hospitalization and Health Care (IRCCS) San Camillo Rehabilitation Hospital Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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