{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:34:53Z","timestamp":1770021293953,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union under the Seventh Framework People Programme","award":["316978"],"award-info":[{"award-number":["316978"]}]},{"name":"European Union under the Seventh Framework People Programme","award":["278948"],"award-info":[{"award-number":["278948"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tourette's disorder and attention\u2010deficit\/hyperactivity disorder often co\u2010occur and have both been associated with structural variation of the basal ganglia. However, findings are inconsistent and comorbidity is often neglected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T1\u2010weighted magnetic resonance images from children (n\u2009=\u2009141, 8 to 12 years) with Tourette's disorder and\/or attention\u2010deficit\/hyperactivity disorder and controls were processed with the Oxford Centre for Functional MRI [Magnetic resonance imaging] of the Brain (FMRIB) integrated registration and segmentation tool to determine basal ganglia nuclei volume and shape. Across all participants, basal ganglia nuclei volume and shape were estimated in relation to Tourette's disorder (categorical), attention\u2010deficit\/hyperactivity disorder severity (continuous across all participants), and their interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis revealed no differences in basal ganglia nuclei volumes or shape between children with and without Tourette's disorder, no association with attention\u2010deficit\/hyperactivity disorder severity, and no interaction between the two.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no evidence that Tourette's disorder, attention\u2010deficit\/hyperactivity disorder severity, or a combination thereof are associated with structural variation of the basal ganglia in 8\u2010 to 12\u2010year\u2010old patients. \u00a9 2016 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.26849","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T09:32:59Z","timestamp":1478770379000},"page":"601-604","source":"Crossref","is-referenced-by-count":17,"title":["<scp>B<\/scp>asal ganglia structure in Tourette's disorder and\/or attention\u2010deficit\/hyperactivity disorder"],"prefix":"10.1002","volume":"32","author":[{"given":"Natalie J.","family":"Forde","sequence":"first","affiliation":[{"name":"University of Groningen University Medical Center Groningen, Department of Psychiatry Groningen The Netherlands"},{"name":"Radboud University Medical Center Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel P.","family":"Zwiers","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jilly","family":"Naaijen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie E. 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