{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:43:24Z","timestamp":1790430204615,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG, HO2402\/6\u20102"],"award-info":[{"award-number":["DFG, HO2402\/6\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: Several morphometric magnetic resonance imaging parameters may serve for differential diagnosis of parkinsonism. The objective of this study was to identify which performs best in clinical routine.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: We acquired multicentric magnetization\u2010prepared rapid gradient echo sequences in patients with Parkinson's disease (n=204), progressive supranuclear palsy (n=106), multiple system atrophy\u2010cerebellar, (n\u2009=\u200921); multiple system atrophy\u2010parkinsonian (n\u2009=\u200960), and healthy controls (n\u2009=\u200973), performed manual planimetric measurements, and calculated receiver operator characteristics with leave\u2010one\u2010out cross\u2010validation to propose cutoff values.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: The midsagittal midbrain area was reduced in PSP versus all other groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The midsagittal pons area was reduced in MSA\u2010cerebellar, MSA\u2010parkinsonian, and PSP versus PD patients and healthy controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The midbrain\/pons area ratio was lower in PSP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and higher in MSA\u2010cerebellar and MSA\u2010parkinsonian versus PD and PSP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: The midsagittal midbrain area most reliably identified PSP, the midsagittal pons area MSA\u2010cerebellar. The midbrain\/pons area ratio differentiated MSA\u2010cerebellar and PSP better than the magnetic resonance\u2010Parkinson index. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26921","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T04:40:32Z","timestamp":1486010432000},"page":"778-782","source":"Crossref","is-referenced-by-count":78,"title":["Manual MRI morphometry in Parkinsonian syndromes"],"prefix":"10.1002","volume":"32","author":[{"given":"Leona","family":"M\u00f6ller","sequence":"first","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"S\u00fcdmeyer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, and Department of Neurology Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Klinikum Ernst von Bergmann Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Hilker","sequence":"additional","affiliation":[{"name":"Departement of Neurology Johann Wolfgang Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Hattingen","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Johann Wolfgang Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical University Center Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Amtage","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Center Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar H.","family":"Pinkhardt","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Respondek","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"},{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-9925","authenticated-orcid":false,"given":"Maria","family":"Stamelou","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"},{"name":"Parkinson's Disease and Movement Disorders Department, HYGEIA Hospital, Athens, Greece and Second Dept. of Neurology, Attikon Hospital University of Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Children and Youth Medicine Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-7939","authenticated-orcid":false,"given":"Alfons","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, and Department of Neurology Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Knake","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00fcrgen","family":"Huppertz","sequence":"additional","affiliation":[{"name":"Swiss Epilepsy Center Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Marburg Germany"},{"name":"Department of Neurology Medical University Center Freiburg Freiburg Germany"},{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70042-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00662-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10680"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00166-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6641-3_11"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000165960.04422.D0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2453061703"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23529"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e55d0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.7.1076"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(03)00014-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203342.77115.bf"},{"issue":"6","key":"e_1_2_8_16_1","first-page":"927","article-title":"MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease","volume":"25","author":"Righini A","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00767.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318292a2d2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000437347.92583.fc"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24968"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23351"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26715"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1402"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10562"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.26921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.26921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:47:44Z","timestamp":1760950064000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.26921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/mds.26921"],"URL":"https:\/\/doi.org\/10.1002\/mds.26921","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}