{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:15:41Z","timestamp":1790874941959,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Capital Region Psychiatry"},{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Few studies have investigated mortality risk in individuals with tic disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person\u2010years of follow\u2010up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : The risk of premature death was higher among individuals with tic disorders (mortality rate ratio, 2.02; 95% CI, 1.49\u20102.66) and with Tourette syndrome (mortality rate ratio, 1.63; 95% CI, 1.11\u20102.28) compared with controls. After the exclusion of individuals with comorbid attention\u2010deficit\/hyperactivity disorder, obsessive\u2010compulsive disorder, and substance abuse, tic disorder remained associated with increased mortality risk (mortality rate ratio, 2.30; 95% CI, 1.57\u20103.23), as did also Tourette Syndrome (mortality rate ratio, 1.81; 95% CI, 1.11\u20132.75).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : These results are of clinical significance for clinicians and advocacy organizations. Several factors may contribute to this increased risk of premature death, and more research mapping out these factors is needed. \u00a9 2017 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.26939","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T03:56:15Z","timestamp":1490414175000},"page":"605-609","source":"Crossref","is-referenced-by-count":37,"title":["Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome"],"prefix":"10.1002","volume":"32","author":[{"given":"Sandra M.","family":"Meier","sequence":"first","affiliation":[{"name":"National Centre for Register\u2010Based Research NCRR, Aarhus University Aarhus V Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Denmark"},{"name":"Child and Adolescent Mental Health Centre \u2014 Mental Health Services Capital Region Copenhagen Region Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Dalsgaard","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010Based Research NCRR, Aarhus University Aarhus V Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben B.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010Based Research NCRR, Aarhus University Aarhus V Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Denmark"},{"name":"CIRRAU \u2014 Centre for Integrated Register\u2010based Research Aarhus University Aarhus V Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Leckman","sequence":"additional","affiliation":[{"name":"Yale Child Study Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin J.","family":"Plessen","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Denmark"},{"name":"Child and Adolescent Mental Health Centre \u2014 Mental Health Services Capital Region Copenhagen Region Denmark"},{"name":"Department of Clinical Medicine Faculty of Health Sciences, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10597-011-9465-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.03.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0223-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-012-0362-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.09.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.071050"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-016-0823-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjop.12118"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2502"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61684-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.3105"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826089109056241"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"issue":"3","key":"e_1_2_7_15_1","first-page":"263","article-title":"The Danish National Hospital Register. 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