{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:06:02Z","timestamp":1790417162605,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> Alzheimer's disease copathology is common in PD at autopsy. In non\u2010PD subjects with mild cognitive impairment, tau depositions can be detected using 18F\u2010AV\u20101451 PET. We hypothesized that 18F\u2010AV\u20101451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> To describe tau aggregation in PD patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010six PD patients and 23 controls had 18F\u2010AV\u20101451 PET and neuropsychological assessment to detect mild cognitive impairment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel\u2010wise analyses showed no correlation with cognitive domain z\u2010scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our results indicate that tau pathology, as detected by 18F\u2010AV\u20101451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26961","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:04:16Z","timestamp":1488513856000},"page":"922-927","source":"Crossref","is-referenced-by-count":54,"title":["In <scp>V<\/scp>ivo cortical tau in Parkinson's disease using 18F\u2010AV\u20101451 positron emission tomography"],"prefix":"10.1002","volume":"32","author":[{"given":"Allan K.","family":"Hansen","sequence":"first","affiliation":[{"name":"Dept of Nuclear Medicine &amp; PET Centre, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene Flensborg","family":"Damholdt","sequence":"additional","affiliation":[{"name":"Unit of Psychooncology and Health psychology, Dept of Psychology and Behavioral Sciences Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana D.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Dept of Nuclear Medicine &amp; PET Centre, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Dept of Nuclear Medicine &amp; PET Centre, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Parbo","sequence":"additional","affiliation":[{"name":"Dept of Nuclear Medicine &amp; PET Centre, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Ismail","sequence":"additional","affiliation":[{"name":"Dept of Nuclear Medicine &amp; PET Centre, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Dept of Neurology, Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Dept of Nuclear Medicine &amp; 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