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Research during the past 3 decades in spinocerebellar ataxia type 2 has revealed a large body of evidence suggesting that many disease features precede the manifest cerebellar syndrome, which delineates the prodromal stage of this disorder. This stage is defined by clinical, imaging, and functional criteria, which are supported by early molecular events demonstrated in animal models. Knowledge regarding prodromal spinocerebellar ataxia type 2 provides insight into the mechanisms underlying neurodegeneration from the early stages, which enables the design of promising disease\u2010modifying clinical trials through the identification of the optimum moment to begin the therapies, the appropriate selection of individuals, and the identification of sensitive outcome measures. The management of patients in prodromal spinocerebellar ataxia type 2 may raise ethical dilemmas related to predictive diagnosis and early interventions, which impose new challenges to clinical and therapeutic research. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.26969","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:05:10Z","timestamp":1488513910000},"page":"708-718","source":"Crossref","is-referenced-by-count":23,"title":["<scp>P<\/scp>rodromal spinocerebellar ataxia type 2: Prospects for early interventions and ethical challenges"],"prefix":"10.1002","volume":"32","author":[{"given":"Luis","family":"Vel\u00e1zquez\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Centre for the Research and Rehabilitation of Hereditary Ataxias Holgu\u00edn 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