{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:44:21Z","timestamp":1790693061422,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Center for Applied Studies in Health Economics and Dr. Huang's internal funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Using a large U.S. claims database (MarketScan), we investigated the controversy surrounding the role of statins in Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case\u2010control analysis. First, we identified 2322 incident PD cases having a minimum of 2.5 years of continuous enrollment prior to earliest diagnosis code or prescription of antiparkinson medication. A total of 2322 controls were then matched individually by age, gender, and a follow\u2010up window to explore the relationship of statin use with incident PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statin usage was significantly associated with PD risk, with the strongest associations being for lipophilic (odds ratio = 1.58, <jats:italic>P<\/jats:italic> &lt; .0001) versus hydrophilic (odds ratio = 1.19, <jats:italic>P<\/jats:italic> = .25) statins, statins plus nonstatins (odds ratio = 1.95, <jats:italic>P<\/jats:italic> &lt; .0001), and for the initial period after starting statins (&lt;1 year odds ratio = 1.82, 1\u20102.5 years odds ratio = 1.75, and \u22652.5 years odds ratio = 1.37; <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> &lt; .0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of statin (especially lipophilics) was associated with higher risk of PD, and the stronger association in initial use suggests a facilitating effect. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27006","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T07:15:54Z","timestamp":1491376554000},"page":"913-917","source":"Crossref","is-referenced-by-count":88,"title":["Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database"],"prefix":"10.1002","volume":"32","author":[{"given":"Guodong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Department of Neurology Pennsylvania State University College of Medicine Hershey Pennsylvania 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