{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:33:45Z","timestamp":1781343225701,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:00:00Z","timestamp":1495843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS077946"],"award-info":[{"award-number":["R01NS077946"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: There is a need for patient\u2010reported outcome measures that capture the impact that motor impairments have on health\u2010related quality of life in individuals with Huntington's disease.<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold>: The objectives of this study were to establish the reliability and validity of new physical functioning patient\u2010reported outcome measures in Huntington's disease.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: A total of 510 individuals with Huntington's disease completed 2 Quality of Life in Neurological Disorders (Lower Extremity Function and Upper Extremity Function) and 3 Huntington's Disease Health\u2010Related Quality of Life (Chorea, Speech Difficulties, and Swallowing Difficulties) measures. Clinician\u2010rated and generic self\u2010report measures were also administered.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Reliabilities for the new patient reported physical functioning measures were excellent (all Cronbach's \u03b1\u2009&gt;\u2009.92). Convergent, discriminant validity and known group validity was supported.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: The results provide psychometric support for new patient\u2010reported physical functioning measures and the fact that these measures can be used as clinically meaningful endpoints in Huntington's disease research and clinical practice. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27046","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T06:23:03Z","timestamp":1495866183000},"page":"1096-1102","source":"Crossref","is-referenced-by-count":14,"title":["Patient\u2010reported outcomes in Huntington's disease: Quality of life in neurological disorders (Neuro\u2010QoL) and Huntington's disease health\u2010related quality of life (HDQLIFE) physical function measures"],"prefix":"10.1002","volume":"32","author":[{"given":"Noelle 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