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Initially developed in the treatment of strabismus and neurologic movement disorders, the use of botulinun neurotoxin has been expanding during the past 3 decades to include the treatment of a variety of ophthalmologic, gastrointestinal, urologic, orthopedic, dermatologic, dental, secretory, painful, cosmetic, and other conditions. In addition to onabotulinumtoxinA (Botox), abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin), and RimabotulinumtoxinB (Myobloc or NeuroBloc) there are other novel botulinun neurotoxin products currently in development. With a better understanding of the cellular mechanisms of botulinun neurotoxin and advances in biotechnology, future botulinun neurotoxin products will likely be even more effective and customized to the specific indication and tailored to the needs of the patients. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27072","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T02:54:56Z","timestamp":1498100096000},"page":"1131-1138","source":"Crossref","is-referenced-by-count":226,"title":["Botulinum toxin: State of the art"],"prefix":"10.1002","volume":"32","author":[{"given":"Joseph","family":"Jankovic","sequence":"first","affiliation":[{"name":"Parkinson's Disease Center and Movement Disorders Clinic Department of Neurology, Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.321"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.56.1.80-99.1992"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"120","article-title":"Botulinum toxin for cranial\u2010cervical dystonia: a double\u2010blind controlled study","volume":"36","author":"Jankovic J","year":"1986","journal-title":"Neurology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.4.616"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92070-2"},{"key":"e_1_2_7_9_1","first-page":"1","volume-title":"Therapy With Botulinum Toxin","author":"Jankovic J","year":"1994"},{"key":"e_1_2_7_10_1","first-page":"1","volume-title":"Scientific and Therapeutic Aspects of Botulinum Toxin","author":"Brin MF","year":"2002"},{"key":"e_1_2_7_11_1","first-page":"1","volume-title":"Botulinum Toxin. 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