{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:16:50Z","timestamp":1783545410559,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 17 patients were reviewed, comparing presurgical, short\u2010term (0\u201048 months), and long\u2010term (\u226548 months) follow\u2010up. The primary end point was the composite activities of daily living\/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a 21.6% improvement (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) in the composite activities of daily living\/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long\u2010term follow\u2010up (8 of 17). The latency of symptoms on standing significantly improved, both in the short\u2010term (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and in the long\u2010term (<jats:italic>P<\/jats:italic>\u2009=\u20090.018). Three patients obtained no\/minimal benefit from the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27082","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T06:48:44Z","timestamp":1497941324000},"page":"1240-1244","source":"Crossref","is-referenced-by-count":40,"title":["Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry"],"prefix":"10.1002","volume":"32","author":[{"given":"Aristide","family":"Merola","sequence":"first","affiliation":[{"name":"Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Fasano","sequence":"additional","affiliation":[{"name":"Division of Neurology, Movement disorders center, University of Toronto Canada Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Krembil Research Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhar","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill L.","family":"Ostrem","sequence":"additional","affiliation":[{"name":"UCSF Movement Disorders and Neuromodulation Center, Department of Neurology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fiorella","family":"Contarino","sequence":"additional","affiliation":[{"name":"Department of Neurology Academic Medical Center Amsterdam The Netherlands"},{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Neurology Haga Teaching Hospital The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical School Hannover, MHH Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universitaetsmedizin Mannheim, Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan T.","family":"Klassen","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Fleur","family":"van Rootselaar","sequence":"additional","affiliation":[{"name":"Department of Neurology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Regidor","sequence":"additional","affiliation":[{"name":"Functional Neurosurgery Unit Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Duker","sequence":"additional","affiliation":[{"name":"Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Ondo","sequence":"additional","affiliation":[{"name":"Methodist Neurological Institute Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Guridi","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, Clinica Universidad de Navarra Navarra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Wagle Shukla","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Movement Disorders and Neurorestoration McKnight Brain Institute Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"Mandybur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Cincinnati College of Medicine. Mayfield Clinic\u2010 Neurosurgeon Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Movement Disorders and Neurorestoration McKnight Brain Institute Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Schleswig\u2010Holstein, Christian\u2010Albrechts University Kiel Germany"},{"name":"Dept. of Neurology School of Medicine and Health Sciences \u2010 European Medical School, University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Starr","sequence":"additional","affiliation":[{"name":"UCSF Department of Neurological Surgery University of California San Francisco San Francisco California 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