{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:35:24Z","timestamp":1790678124589,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008236","name":"Roger de Spoelberch Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Dopamine replacement therapy in PD has been associated with both behavioral addictions and dopamine addiction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    : To investigate potential association between\n                    <jats:sc>l<\/jats:sc>\n                    \u2010dopa induced neuropsychiatric fluctuations and addictions in PD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : A cohort of 102 patients with PD suffering from motor complications of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010dopa treatment was prospectively analyzed. We evaluated dopamine addiction, behavioral addictions, and neuropsychiatric fluctuations using the Ardouin scale of behavior in PD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Patients with (n\u2009=\u200951) or without (n\u2009=\u200951) neuropsychiatric fluctuations did not differ in age, disease duration, medication, or UPDRS III motor score during\n                    <jats:italic>on<\/jats:italic>\n                    and\n                    <jats:italic>off<\/jats:italic>\n                    drug condition. Patients with neuropsychiatric fluctuations had a higher H &amp; Y stage in\n                    <jats:italic>off<\/jats:italic>\n                    \u2010drug condition. A multivariate model showed that dopamine addiction (odds ratio: 8.9;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02) and behavioral addictions (odds ratio: 3.76;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.033) were more frequent in the presence of neuropsychiatric fluctuations. Behavioral addictions and dopamine addiction were more frequent in the presence than in the absence of\n                    <jats:italic>on<\/jats:italic>\n                    \u2010drug euphoria (46% vs. 13.9%;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001 and 27% vs 6.2 %;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003), while conversely, no association emerged between dopamine or behavioral addictions and presence of\n                    <jats:italic>off<\/jats:italic>\n                    \u2010drug dysphoria. Patients with neuropsychiatric fluctuations had a poorer quality of life and a more frequent history of anxiety disorder.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : The psychostimulant effects of dopamine treatment during\n                    <jats:italic>on<\/jats:italic>\n                    \u2010drug euphoria, rather than avoidance of\n                    <jats:italic>off<\/jats:italic>\n                    \u2010drug dysphoria, appear to drive both behavioral addictions and abuse of medication. \u00a9 2017 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.27101","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:06:40Z","timestamp":1500876400000},"page":"1566-1573","source":"Crossref","is-referenced-by-count":32,"title":["Psychostimulant effect of dopaminergic treatment and addictions in Parkinson's disease"],"prefix":"10.1002","volume":"32","author":[{"given":"Benoit","family":"Delpont","sequence":"first","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Lhomm\u00e9e","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"},{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Klinger","sequence":"additional","affiliation":[{"name":"Service de Neurologie C, Universit\u00e9 Lyon I, Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer Lyon France"},{"name":"CNRS, UMR 5229, Centre de Neurosciences Cognitives Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"},{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Bichon","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"},{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Fraix","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"},{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Castrioto","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"},{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Quesada","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Scientifique de la DRCI et Centre d'Investigation Clinique, CHU de Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"P\u00e9lissier","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kistner","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Neurology Department, CHU Grenoble Alpes and Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Carnicella","sequence":"additional","affiliation":[{"name":"Grenoble Institut des Neurosciences, Inserm, U1216 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Department of Basic Neurosciences Medical Faculty, University of Geneva, Geneva, Switzerland; Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Broussolle","sequence":"additional","affiliation":[{"name":"Service de Neurologie C, 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