{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:00:08Z","timestamp":1792094408308,"version":"4.4.0"},"reference-count":299,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:00:00Z","timestamp":1504915200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple\u2010author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state\u2010of\u2010the\u2010art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27115","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T05:35:11Z","timestamp":1504935311000},"page":"1264-1310","source":"Crossref","is-referenced-by-count":804,"title":["Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy"],"prefix":"10.1002","volume":"32","author":[{"given":"J.A.","family":"Obeso","sequence":"first","affiliation":[{"name":"HM CINAC Hospital Universitario HM Puerta del Sur, Mostoles Madrid Spain"},{"name":"Universidad CEU San Pablo Madrid Spain"},{"name":"CIBERNED Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-9925","authenticated-orcid":false,"given":"M.","family":"Stamelou","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"},{"name":"Parkinson's Disease and Movement Disorders Department, HYGEIA Hospital and Attikon Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Poewe","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease Toronto Western Hospital Toronto Canada"},{"name":"Department of Medicine University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Parkinson's Disease and Mental Illness Research, Education and Clinical Centers (PADRECC and MIRECC) Corporal Michael J. 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