{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:05:53Z","timestamp":1790129153185,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Impulse control disorders can be triggered by dopamine replacement therapies in patients with PD. Using resting\u2010state functional MRI, we investigated the intrinsic brain network connectivity at baseline in a cohort of drug\u2010naive PD patients who successively developed impulse control disorders over a 36\u2010month follow\u2010up period compared with patients who did not.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Baseline 3\u2010Tesla MRI images of 30 drug\u2010naive PD patients and 20 matched healthy controls were analyzed. The impulse control disorders' presence and severity at follow\u2010up were assessed by the Questionnaire for Impulsive\u2010Compulsive Disorders in Parkinson's Disease Rating Scale. Single\u2010subject and group\u2010level independent component analysis was used to investigate functional connectivity differences within the major resting\u2010state networks. We also compared internetwork connectivity between patients. Finally, a multivariate Cox regression model was used to investigate baseline predictors of impulse control disorder development.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    At baseline, decreased connectivity in the default\u2010mode and right central executive networks and increased connectivity in the salience network were detected in PD patients with impulse control disorders at follow\u2010up compared with those without. Increased default\u2010mode\/central executive internetwork connectivity was significantly associated with impulse control disorders development (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Our findings demonstrated that abnormal brain connectivity in the three large\u2010scale networks characterizes drug\u2010naive PD patients who will eventually develop impulse control disorders while on dopaminergic treatment. We hypothesize that these divergent cognitive and limbic network connectivity changes could represent a potential biomarker and an additional risk factor for the emergence of impulse control disorders. \u00a9 2017 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.27139","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T07:33:55Z","timestamp":1506411235000},"page":"1710-1719","source":"Crossref","is-referenced-by-count":66,"title":["Intrinsic brain connectivity predicts impulse control disorders in patients with Parkinson's disease"],"prefix":"10.1002","volume":"32","author":[{"given":"Alessandro","family":"Tessitore","sequence":"first","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"De Micco","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"di Nardo","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"Neuropsychology Laboratory Department of Psychology, University of Campania \u201cLuigi Vanvitelli\u201d Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"},{"name":"MRI Research Center SUN\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno Baronissi (SA) 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