{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:21:11Z","timestamp":1791580871418,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 NS072187"],"award-info":[{"award-number":["P50 NS072187"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 NS097261"],"award-info":[{"award-number":["R35 NS097261"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive impairment is one of the core features of progressive supranuclear palsy. This study aimed to clarify the profile of cognitive impairment and its underlying pathology in progressive supranuclear palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed medical records to evaluate the pattern and severity of cognitive impairment in 121 autopsy\u2010confirmed progressive supranuclear palsy patients. A subset of 37 patients underwent neuropsychological evaluation as part of their clinical workup. The burden of progressive supranuclear palsy\u2010related tau pathology (neurofibrillary tangles\/pretangles, coiled bodies, tufted astrocytes, and threads) was semiquantitatively scored in 20 vulnerable brain regions. Concurrent pathologies potentially associated with cognitive impairment, such as Alzheimer's\u2010type pathology, were also assessed. To evaluate possible genetic risk factors for cognitive impairment, genetic analysis for\n                      <jats:italic>APOE<\/jats:italic>\n                      and\n                      <jats:italic>MAPT<\/jats:italic>\n                      was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety patients (74%) had documented cognitive impairment based on neurologic evaluation. In a subgroup with neuropsychological testing (n = 37), executive functioning was the most severely impaired cognitive domain. A global cognitive impairment index (Spearman's rho, \u22120.49;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005) and executive functioning were negatively correlated with total tau burden (Spearman's rho, \u22120.51;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003), but not correlated with the Alzheimer's\u2010type pathology.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 carriers had more severe amyloid pathology, but total tau burden and a global cognitive impairment index did not differ from\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 noncarriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cognitive impairment in progressive supranuclear palsy, most notably executive dysfunction, is associated with severity of progressive supranuclear palsy\u2010related tau pathology. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.27198","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T03:36:42Z","timestamp":1509334602000},"page":"1772-1779","source":"Crossref","is-referenced-by-count":52,"title":["Cognitive impairment in progressive supranuclear palsy is associated with tau burden"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9700","authenticated-orcid":false,"given":"Shunsuke","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Parks","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kasanuki","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sanchez\u2010Contreras","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology (Behavioural Neurology &amp; Movement Disorders) Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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