{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:04:10Z","timestamp":1762272250624,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG002449"],"award-info":[{"award-number":["HG002449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of 247 participants, 36 (14.6%) phenoconverted. Mean follow\u2010up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59\u20108.71), high use hazard ratio 4.05 (95% confidence interval 1.18\u201013.96).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27239","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T05:39:12Z","timestamp":1514957952000},"page":"472-478","source":"Crossref","is-referenced-by-count":13,"title":["Selected health and lifestyle factors, cytosine\u2010adenine\u2010guanine status, and phenoconversion in Huntington's disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Caroline","family":"Tanner","sequence":"first","affiliation":[{"name":"Parkinson's Disease Research, Education and Clinical Center, Neurology San Francisco Veterans Affairs Medical Center San Francisco California USA"},{"name":"Department of Neurology University of California\u2013San Francisco San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Marder","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Psychiatry, Taub Institute for Research on the Aging Brain, Gertrude H. Sergievsky Center Columbia University College of Physicians and Surgeons New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Eberly","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Biglan","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis Indiana USA"},{"name":"Department of Neurology University of Rochester New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oakes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology University of Rochester New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Shoulson","sequence":"additional","affiliation":[{"name":"Department of Neurology Georgetown University Washington D.C. USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Huntington Study Group Prospective Huntington At\u2010Risk Observational Study Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.003"},{"issue":"11","key":"e_1_2_8_4_1","first-page":"1382","article-title":"Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease","volume":"70","author":"Marder K","year":"2013","journal-title":"JAMA Neurology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b04aa2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2736"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.195"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20882"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.05.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.20.2674"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25076"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.02.032"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.09.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00411-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.04.047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.04.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4903"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-011-1968-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1992.tb121455.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7559-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23385"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199001000-00010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.003"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.27239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:44:26Z","timestamp":1760967866000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.27239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/mds.27239"],"URL":"https:\/\/doi.org\/10.1002\/mds.27239","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}